Leland Stanford Junior University

University of California

Novocure Gmbh

The University of Mississippi

Other

General Electric Company

Sanofi

Global Life Sciences Solutions Operations UK Ltd

The Scripps Research Institute

Kyungpook National University Industry-Academic Cooperation Foundation

Sanjiv Sam Gambhir

Andreas M Loening

Ramasamy Paulmurugan

Zhen Cheng

Anna M Wu

Michelle Louise James

Shan X Wang

Richard H Kimura

Viswam Siva Nair

Bin Shen

Frederick T Chin

Edwin Chang

Ray Pritha

Seung-min Park

Mohammad Namavari

Arutselvan Natarajan

Moshe Giladi

Tali Voloshin-Sela

Utkan Demirci

Jianghong Rao

Aihua Fu

Benjamin Joseph Hackel

Srabani Bhaumik

Christopher R McCurdy

Byeong-Cheol Ahn

Shahriar Yaghoubi

Abhijit De

Peter D Olcott

Jennifer R Cochran

Craig Steven Levin

Parag Mallick

Adam De La Zerda

Christian Lange

Ian Walton

Jochen Kruip

Anders Carlsson

Matthew S Bogyo

Joseph C Wu

Christophe Mesangeau

Min-kyung So

Yaara Porat

Fei Liu

Shay Keren

Hongguang Liu

Chenjie Xu

Ingo Focken

Moritz F Kircher

Sandip Biswal

Mathias Gebauer

Peter Kuhn

Natesh Parashurama

Gayatri Gowrishankar

Ananth Srinivasan

Cristina Zavaleta

Chirag B Patel

Samira Guccione

Galia Blum

Michael F Carey

Brian Lee

Susanta K Sarkar

Tianjia Jessie Ge

Jelena Levi

Israt Shamima Alam

Robert Teed

Beverly S Mitchell

Joseph Ching-Ming Wu

Feng Cao

Sri-rajasekhar Kothapalli

David Guagliardo

Zheng Miao

Gang Ren

Levi Jelena

Gary M Glazer

Aloma L D'Souza

Dawson Wong

Paulmurugan Ramasamy

Alicia Berger

Meera Iyer

Ophir Vermesh

Anand Kolatkar

Amin Aalipour

Diego Escobedo

Sunil Bodapati

Timothy Witney

Alexander Lozano

Lily Wu

Chin Chun Ooi

Joanne Zhang

Daeyoun Won

Sarah M Hooper

Idan Steinberg

Mirwais Wardak

Ohad Ilovich

Jesse Jokerst

Deepak Behera

Lingyun Xu

Nick Hughes

Carsten H Nielsen

Corrine Gaye Beinat

John A Ronald

A method for photoacoustic imaging is performed by measuring RF time samples from transducer elements, and reconstructing an estimated initial pressure image from the measured RF time samples and a pre-calculated forward model matrix. The reconstructing involves minimizing the difference between the pre-calculated forward model matrix applied to the image estimate and the measured RF time samples by implementing a superiorized modified conjugate gradient least squares algorithm to minimize the total variation norm. The model matrix factors each of the transducer elements into sub-wavelength mathematical elements.

Real-time photoacoustic imaging using a precise forward model and fast iterative inverse

A device ('the ExoTIC device') for the isolation of extracellular vesicles from an extracellular vesicle-containing sample in which the sample is flowed through a membrane in a flow chamber to capture and purify the extracellular vesicles on the membrane. The extracellular vesicles may be washed and collected and utilized in any one of a number of ways including, but not limited to, identifying biomarkers of a disease, identifying the presence of a biomarker in a patient to determine whether a patient has a disease, and therapeutically treating existing diseases by re-introducing the extracellular vesicles, potentially modified, back into a body.

Exosome-total-isolation-chip (ExoTIC) device for isolation of exosome-based biomarkers

Devices, systems, and methods are provided for monitoring or analyzing excreta of a subject using a toilet. In one embodiment, the device includes a housing mounted adjacent a toilet bowl, a urinalysis module for deploying urinalysis strips into the toilet bowl to collect a urine sample from a subject's urine stream delivered into the toilet bowl and a urinalysis sensor to acquire data from the urinalysis strip related to the urine sample, and a stool analysis module including a camera oriented into the toilet bowl to provide images of contents of the toilet bowl. In addition, the device may include a uroflowmetry module and/or a biometric identification module. One or more sensors are provided for identifying when a subject uses the toilet, and a processor activates one or more of the modules when the sensors indicate a subject is using the toilet.

Smart toilet for human health monitoring

Certain substances (e.g., large molecules) that ordinarily cannot traverse the cell membrane of cells can be introduced into cells by applying an alternating electric field to the cell for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the cell membrane. Once the permeability of the cell membrane has been increased, the substance is able to cross the cell membrane. This approach is particularly useful in the context of cancer cells (e.g., glioblastoma).

Using alternating electric fields to increase cell membrane permeability

Systems and methods for synthetic medical image generation in accordance with embodiments of the invention are illustrated. One embodiment includes a synthetic medical image generation system, including a processor, and a memory containing an image synthesis application, where the image synthesis application directs the processor to obtain source image data generated by at least one medical imaging device, where the source image data describes a functional medical image taken of a patient administered with a first imaging agent, and synthesize a predicted medical image of the patient that depicts the patient as if they were administered with a second imaging agent, wherein the first imaging agent and the second imaging agent are different imaging agents.

Systems and methods for synthetic medical image generation

Exosome-Total-Isolation-Chip (ExoTIC) device for isolation of exosome-based biomarkers

An expression vector, comprising a first reporter nucleic acid sequence operably linked to a first expression control sequence comprising a promoter; and a second reporter nucleic acid sequence operably linked to a second expression control sequence that comprises a response element that is activated or inactivated as one or more of the cells differentiate or dedifferentiate. Methods and kits for imaging and monitoring stem cells comprising the expression vector are also provided.

Composition and method for imaging stem cells

Embodiments of the present disclosure provide for labeled probes such as labeled maltoside probes and labeled maltotriose probes, methods of making labeled probes, pharmaceutical compositions including labeled probes, methods of using labeled probes, methods of diagnosing, localizing, monitoring, and/or assessing bacterial infections, using labeled probes, kits for diagnosing, localizing, monitoring, and/or assessing bacterial infections, using labeled probes, and the like.

Probes and methods of imaging a bacterial infection

Provided herein are targeted photoacoustic compounds and formulations thereof that can contain a photoacoustic signaling moiety operatively coupled to a targeting moiety. Also provided herein are methods of imagining a subject using the targeted photoacoustic compounds and formulations thereof provided herein.

Targeted photoacoustic compounds, formulations, and uses thereof

In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to Raman imaging devices (e.g., Raman endoscope probes), methods of using Raman agents and Raman imaging devices to image or detect a signal, and the like.

Raman imaging devices and methods of molecular imaging

The present disclosure provides a positron emission tomography (PET)-detectable 1-((2-fluoro-6-[F]fluorophenyl)sulfonyl)-4-((4-methoxyphenyl)sulfonyl)piperazine ([F]DASA-23) probe that can selectively bind to the pyruvate kinase variant M2 (PKM2) found in cancer cells, such as of human glioma. Given the importance of PKM2 in the regulation of tumor metabolism, there is an on-going need to non-invasively measure its expression through the development of PKM2-specific radiopharmaceuticals. Precursors useful for the synthesis of the radiolabeled [F]DASA-23-PKM2-specific probe and related compounds, and their methods of synthesis, are provided. Since the half-life of theF isotope is approximately 110 min, it is advantageous for a practitioner to attach the radionuclide to the precursor shortly before administration. Therefore, a precursor compound suitable for receiving the radionuclide and capable of specifically binding to the PKM2 variant can be provided.

Imaging tumor glycolysis by non-invasive measurement of pyruvate kinase M2

Embodiments of the present disclosure provide for radionuclide probes, methods of using the radionuclide probes, methods of detecting an optical signal from radionuclides, methods of detecting an optical signal from a quantum dot(s) that receives optical energy from a radionuclide(s), system for analyzing optical energy emitted by a radionuclide(s), system for imaging a target within a living subject or a sample, methods of imaging a disease or condition, and the like.

Optical imaging probes, optical imaging systems, methods of optical imaging, and methods of using optical imaging probes

A method for identification of circulating tumor cells (CTCs) in a blood sample uses magnetic enrichment and a nanowell assay. The CTCs are magnetically labeled with cancer cell markers conjugated to magnetic nanoparticles and then separated by passing the blood sample through a magnetic sifter. The enriched CTCs are then loaded into a microfluidic single-cell molecular assay comprising an array of 25,600 or more nanowells, each containing at most a single one of the CTCs. Using multiple fluorescent gene markers, simultaneous multiple-color multiplexed gene expression of the CTCs is performed, preferably using RT-PCR. Images of fluorescence signals from individual nanowells are analyzed to identify CTCs.

Molecular analysis using a magnetic sifter and nanowell system

A medical device and method for detection, retrieval or elimination of disease-associated toxins and biomarkers is provided. A plurality of magnets is arranged within a flexible sheath forming a flexible wire. The magnets are magnetically attached to each other, end-to-end, and arranged with their magnetic polarities alternating in direction. The magnetization direction of each of the magnets is orthogonal to the length axis of the flexible wire. The medical device is completely self-contained and does not require a bulky external field source able to maintain strong magnetic field gradients (100-10,000 T/m) along the wire, and at a radial distance (&#x2dc;1 mm) to attract magnetic particles throughout the entire vein diameter at a range of physiologic velocities (1-10 cm/sec). This technology is a major step forward for the clinical relevance of CTC analysis to personalized medicine and introduces a powerful generalizable strategy for enrichment of other rare blood biomarkers.

Intravascular magnetic wire for detection, retrieval or elimination of disease-associated biomarkers and toxins

Growing community of inventors

Portola Valley, CA, United States of America

Sanjiv Sam Gambhir