Allergan, Inc.

Sanjiv Ghanshani

Lance Steward

Kei Roger Aoki

Ester Fernandez-Salas

Joseph Francis

Marcella A Gilmore

Shengwen Li

J Oliver Dolly

Linh Q Le

Yi Liu

Lance E Steward

The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such toxins or chimeras, compositions comprising such toxins or chimeras, and method of producing such toxins or chimeras.

Degradable clostridial toxins

The present specification discloses expression constructs comprising single-chain proteins comprising a di-chain loop region comprising an exogenous protease cleavage site and a protease that can cleave the exogenous protease cleavage site located within the di-chain loop, cell compositions comprising such expression construct, and intracellular methods of converting the single-chain protein into its di-chain form.

Methods of intracellular conversion of single-chain proteins into their di-chain form

Degradable Clostridial toxins

Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.

Activatable clostridial toxins

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Irvine, CA, United States of America

Sanjiv Ghanshani