University of Massachusetts

National Research Council of Canada

Novartis Vaccines and Diagnostics Srl

Children's Hospital & Research Center Oakland

Sanjay Ram

Dennis M Whitfield

Ian C Schoenhofen

Dan M Granoff

Peter A Rice

Sunita Gulati

Douglas T Golenbock

Alberto Visintin

Jutamas Shaughnessy

Tathagat Duttaray

Lisa A Lewis

JoAnne Welsch

Fusion proteins comprising human FH domains 18-20 (FH18-20) linked via an optional linker to IgG Fc, wherein the FH has mutation of D to G at position 1119 in domain 19; FHD1119G/Fc), and methods of use thereof, e.g., to treat pathogen infections.

Factor H-Fc immunotheraphy

has become resistant to almost every conventional antibiotic. Described herein is the use of CMP-nonulosonate analogues to counter gonococcal complement evasion. The nonulosonate sugar is incorporated into the lipooligosaccharide of thewhich in turn reduces the serum resistance of the bacteria. This provides a novel therapeutic strategy against the global threat of multi-drug resistant gonorrhea.

therapeutic based on CMP-nonulosonate sugars

has become resistant to almost every conventional antibiotic. Described herein is the use of CMP-nonulosonate analogs to counter gonococcal complement evasion. The nonulosonate sugar is incorporated into the lipooligosaccharide of thewhich in turn reduces the serum resistance of the bacteria. This provides a novel therapeutic strategy against the global threat of multi-drug resistant

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The invention provides compositions and methods for screening subjects at risk for contracting meningococcal disease and/or at risk for failing to elicit an immunogenic response to a vaccine against. The invention also provides kits for carrying out these screens, and improved vaccines against

Assays for detection of bactericidal anti-Neisserial antibodies using a factor H polypeptide having a human amino acid sequence that mediates binding to Neisserial factor H binding protein (fHBp) are provided, as well as non-human animal models of Neisserial infection.

Growing community of inventors

Worcester, MA, United States of America

Sanjay Ram