Lupin, Inc.

Sanjay Pralhad Kurhade

Venkata Poornapragnacharyulu Palle

Rajender Kumar Kamboj

Neelima Sinha

Navnath Popat Karche

Milind Dattatraya Sindkhedkar

Manojkumar Ramprasad Shukla

Anil Kashiram Hajare

Prathap Sreedharan Nair

Samiron Phukan

Gourhari Jana

Ajay Ramchandra Tilekar

Navnath Bajirao Walke

Sachin Sethi

Sachchidanand Sachchidanand

Pradeep Rangrao Patil

Balasaheb Arjun Gore

Gagan Kukreja

Arun Rangnath Jagdale

Vikas Sitaram Tambe

Vipul Pachpute

Sachin Mahangare

Disclosed is a compound of formula I: wherein Z, m and R-Rare as described herein, as a modulator of nicotinic acetylcholine receptors particularly the &#x3b1;7 subtype, in a subject in need thereof, as well as analogues, prodrugs, isotopically substituted analogs, metabolites, pharmaceutically acceptable salts, polymorphs, solvates, isomers, clathrates, and co-crystal thereof, for use either alone or in combinations with suitable other medicaments, and pharmaceutical compositions containing such compounds and analogues. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like.

Heteroaryl derivatives as alpha7 nAChR modulators

Disclosed are compounds of formula (I), their tautomeric forms, stereoisomers, and pharmaceutically acceptable salts thereof, wherein R-R, R, R, A, M, n, and p are as defined in the specification, pharmaceutical compositions including a compound, tautomer, stereoisomer, or salt thereof, and methods of treating or preventing diseases or disorders, for example, cancer, that are amenable to treatment or prevention by inhibiting the PARP enzyme of a subject. 

Tetrahydroquinazolinone derivatives as PARP inhibitors

Disclosed is a compound of formula (I), wherein Z, m and R-Rare as described herein, as a modulator of nicotinic acetylcholine receptors particularly the &#x3b1;7 subtype, in a subject in need thereof, as well as analogs, prodrugs, isotopically substituted analogs, metabolites, pharmaceutically acceptable salts, polymorphs, solvates, isomers, clathrates, and co-crystal thereof, for use either alone or in combinations with suitable other medicaments, and pharmaceutical compositions containing such compounds and analogs. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like. 

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Pune, India

Sanjay Pralhad Kurhade