Council of Scientific and Industrial Research

Sanjay Narayan Nene

Bhaskar Ganapatrao Gaikwad

Mohan Gopalkrishna Kulkarni

Ramesh Anna Joshi

Uttam Ramrao Kalkote

Rohini Ramesh Joshi

Prashant Purushottam Barve

Milind Yashwant Gupte

Ravindra William Shinde

Sudhir Sharadchandra Kulkarni

Vithal Venkatrao Jogdand

Digambar Vitthal Gokhale

Thottapillil Ravindranathan

Kulbhushan Balwant Bastawde

Madhav Jagannath Thakar

Shamrao Ganapatrao Patil

Bhaskar Dattatraya Kulkarni

Chandrashekhar Narayan Joshi

Vilas Bhiku Chavan

Gandhali Arun Thite

Tushar Ramchandra Deshpande

Bhaskar Dattatreya Kulkarni

Ramchandra Vithal Gadre

The dehydrated alkali metal salts of carboxylic acid are dissolved in the alcohol such as methanol or ethanol or butanol to make their solution in corresponding alcohol. The solution alcohol is further treated with carbon dioxide under pressure or at atmospheric pressure at elevated temperature such as 150 to 200&#xb0; C. The carboxylic acid gets converted into corresponding alkyl ester and calcium carbonate or sodium carbonate or potassium carbonate as the byproduct. Calcium lactate or sodium lactate or sodium acetate or sodium benzoate or sodium salicylate as alkali metal salt solution prepared in methanol or ethanol or butanol when treated with carbon dioxide under pressure or at atmospheric pressure at elevated temperature gets converted to methyl lactate or ethyl lactate or methyl acetate or methyl benzoate or methyl salicylate as product.

Process for preparation of pure alkyl esters from alkali metal salt of carboxylic acid

The present invention provides a commercially viable process for the preparation of highly pure and optically active L-(+)-lactic acid and S-(&#x2212;)-methyl lactate, in high yield, obtained from esterification of aqueous crude lactic acid solution produced by sugar cane juice fermentation broth and methanol in continuous counter current trickle phase approach or in continuous counter current bubble column manner, using stabilizers and the methyl lactate so obtained is recovered and followed by purification of reasonably pure methyl lactate using reagent mixture such as sodium bi-carbonate, mono-ethanolamine or di-ethanolamine, urea or sodium-bicarbonate, mono-ethanolamine or di-ethanolamine, thiourea to reduce the impurity of dimethyl ester of dicarboxylic such as dimethyl oxalate or di-methyl succinate or methyl ester of mono-carboxylic acid such as methyl pyruvate present as an impurity, so as to get highly pure S-(&#x2212;)-methyl lactate followed by hydrolyzing highly pure S-(&#x2212;)-methyl lactate using highly pure lactic acid as a catalyst, using highly pure water as the hydrolysis media and by using pre-treated activated carbon with dilute L-(+)-lactic acid, in batch or continuous mode. This very high pure S-(&#x2212;)-methyl lactate constitutes an important product having interesting possibilities of application at an industrial level, in pharmaceuticals. Highly pure L-(+)-lactic acid thus obtained is used as an acidulant, as a food additive, for pharmaceutical applications, a monomer for making poly-lactic acid, as a monomer to prepare biodegradable polymer which are useful for manufacturing bags, application films, in the field of sanitary field, and has medical applications.

Process for preparing L- (+) -lactic acid

The invention relates to a novel process for the recovery of potassium bitartrate and pectin, sugars, fruit acids as by-products from tamarind pulp.

Process for the recovery of potassium bitartrate and other products from tamarind pulp

A microbial process for the preparation of D(-)-N-carbamoylphenylglycine from DL-5-phenylhydantoin which comprises culturing the strain pseudomonas sp. having Accession No. NCIM 5070 (ATCC 55940) and deposited in National Collection of Industrial Microorganisms (NCIM), National Chemical Laboratory (NCL) (India), having hydantoinase activity, in a medium for 16-20 hours, separating the cells by centrifugation, treating the solid cells obtained with DL-5-phenylhydantoin in buffer, at a temperature in the range of about 25-30&deg; C. for a period of about 2-6 hours, acidifying the mixture to obtain solid D(-)-N-carbamoylphenylglycine, and separating the product by filtration.

Microbial process for the production of D(-)-N-carbamoylphenylglycine

A microbial process for the preparation of D(-)-N-carbamoylphenylglycine from DL-5-phenylhydantoin which comprises culturing the strain pseudomonas sp. having Accession No. NCIM 5070 (ATCC 55940) and deposited in National Collection of Industrial microorganisms (NCIM), National Chemical laboratory (NCL) (India), having hydantoinase activity, in a medium for 16-20 hours, separating the cells by centrifugation, treating the solid cells obtained with DL-5-phenylhydantoin in buffer, at a temperature in the range of about 25-30.degree. C. for a period of about 2-6 hours, acidifying the mixture to obtain solid D(-)-N-carbamoylphenylglycine, and separating the product by filtration.

The invention provides Potassium bitartrate, pectin, L(+) tartaric acid and fruit sugars present in tamarind pulp, which are recovered sequentially by extracting the pulp in water, concentrating and chilling the extract, filtering out potassium bitartrate, precipitating out pectin from the filtrate by addition of acetone, extracting L(+) tartaric acid selectively by complexation with tertiary amine and recovering from the amine layer by back extraction into aqueous layer in the presence of a diluent at around 70.degree. C. followed by concentration and drying of the aqueous layer and treating the raffinate layer from solvent extraction with activated carbon, anion exchange resin, and concentrating to yield sugar containing 70% sugars.

Process for the recovery of tartaric acid and other products from

Growing community of inventors

Pune, India

Sanjay Narayan Nene