Depuy Synthes Products, Inc.

Ethicon, Gmbh

Advanced Technologies and Regenerative Medicine, LLC

Janssen Biotech, Inc.

Sanjay Mistry

Darin J Messina

Anna Gosiewska

Alexander M Harmon

Ian Ross Harris

Anthony J Kihm

Agnieszka Seyda

Chin-Feng Yi

Brian C Kramer

L S Klaudyne Hong

Michael J Romanko

Ls Klaudyne Hong

Sridevi N Dhanaraj

Ziwei Wang

Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions.

Cartilage and bone repair and regeneration using postpartum-derived cells

Cells derived from postpartum placenta and methods for their isolation are provided by the invention. The invention further provides cultures and compositions of the placenta-derived cells. The placenta-derived cells of the invention have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications.

Postpartum cells derived from placental tissue, and methods of making and using the same

Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of ocular tissue using the postpartum-derived cells are also disclosed.

Repair and regeneration of ocular tissue using postpartum-derived cells

Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.

Postpartum cells derived from umbilical cord tissue, and methods of making and using the same

Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.

Regeneration and repair of neural tissue using postpartum-derived cells

Compositions and methods applicable to cell-based or regenerative therapy for ophthalmic diseases and disorders comprising mesenchymal stem cells, particularly those characterized by the expression of at least one of the following surface markers: CD29, CD44, CD105 or CD166, and the lack of expression of at least one of CD14, CD34 or CD45.

Cellular therapy for ocular degeneration

The present invention is directed to methods of treating neurological deficits resulting from injury or disease to the striatum or substanta nigra pars compacta of a human by administering human recombinant GDF5 to the striatum or substanta nigra pars compacta of a human in amounts effective to induce cell populations having the capacity to differentiate towards a dopaminergic phenotype to in fact differentiate towards a dopaminergic phenotype, and to neurotrophic compositions and matrices suitable for use in such treatments.

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Downingtown, PA, United States of America

Sanjay Mistry