Leland Stanford Junior University

The United States Government As Represented by the Department of Veterans Affairs

Sanjay Malhotra

Vineet Kumar

Brian A Zabel

Mallesh Pandrala

Dhanir Tailor

Melissa LaJevic

Angel Resendez

The present disclosure relates to novel boronic acid receptor compounds and their use in methods of quantifying a saccharide appearing in a sample. Provided are methods of measuring the concentration of a saccharide in a sample as well as methods of measuring the concentration of a halogenated saccharide in a sample. In certain aspects the sample is abiological sample and the methods further include correlating the measured concentration of saccharide in the biological sample to the gastrointestinal permeability in the individual. Disclosed are also kits for performing the above methods.

Boronic acid appended naphthyl-pyridinium fluorescent saccharide sensors for early detection of gastrointestinal diseases

Compounds, compositions and methods are provided for the inhibition of GBP1. The subject inhibitor compounds can act by inhibiting GBP1 alone and/or GBP1: pro-survival kinase (e.g. serine/threonine-protein kinase pim-1 (PIM1)) interactions. Aspects of the subject methods include contacting a cellular sample with a GBP 1 inhibitor to inhibit the GBP 1 alone and/or GBP 1: PIM 1 interactions. Also provided are compositions and methods for treating cancer. In certain cases the cancer is resistant towards chemotherapy and radiation therapy.

N-hydroxyethyl didehydroazapodophyllotoxins as GBP1 inhibitors and methods of overcoming treatment resistance in cancer

&#x3b1;-NETA analogs are provided for the treatment of inflammatory disease.

Small molecule CMKLR1 antagonists in inflammatory disease

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Palo Alto, CA, United States of America

Sanjay Malhotra