University of California

Sanjay Kumar Nigam

Hiroyuki Sakurai

Kevin Toivo Bush

Eran Rosines

Henry C Liu

Jizeng Qiao

Provided are drug-transport metabolomics profile assessments and therapies.

Predicting metabolic side effects of transported drugs

Provided are methods and compositions for constructing stable mammalian embryonic epithelial tissues and organs as well as constructing kidney tissue, and treating renal failure. Disclosed are methods of using an active epithelial growth factor having the capability of effectuating induction of growth and morphogenesis is cells.

Methods of tissue generation and tissue engineered compositions

Methods of inducing tubulogenesis and/or branching morphogenesis of kidney cell cultures

Provided are methods and compositions for constructing stable mammalian embryonic epithelial tissues and organs as well as constructing kidney tissue, and treating renal failure. Disclosed are methods of using an active epithelial growth factor having the capability of effectuating induction of growth and morphognesis is cells.

Induction of tubular morphogenesis using pleiotrophin

A method for constructing a stable bioactive mammalian embryonic kidney is described herein. A kidney so constructed requires no artificial support, nor porous man made membranes or tubing to effectuate its biological function of filtering body fluids. A single donor embryonic kidney, or fragment thereof, can produce a great number of functional kidneys suitable for treating subjects with various kidney disorders. It is anticipated that said in vitro produced kidney would be less, or not at all, antigenic when transplanted into a subject, because of its embryonic character and artificial propagation in culture. This method of producing a functional organ can be useful in cloning other organ structures containing inducible epithelial tissues.

Growing community of inventors

Del Mar, CA, United States of America

Sanjay Kumar Nigam