Bone Care International, Inc.

Other

The United States of America As Represented by the Secretary of

Sanjay K Singhal

Robert M Moriarty

Charles W Bishop

Joyce C Knutson

Raju A Penmasta

Liang Guo

Glenville Jones

Stephen Strugnell

Lei Zhao

Ronald L Horst

Timothy A Reinhardt

Nicholas J Koszewski

1&agr;,24(S)-Dihydroxy vitamin D,which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1&agr;,24(S)-dihydroxy vitamin D,starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D,which is converted in six steps to 1&agr;,24(S)-dihydroxy vitamin D,. The syntheses also produced novel intermediates.

Methods for preparation and use of 1&agr;,24(S)-dihydroxy vitamin D2

Methods for preparation and use of 1&agr;,24 (S)-dihydroxy vitamin D2

1.alpha.,24(S)-Dihydroxy vitamin D.sub.2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1.alpha.,24(S)-dihydroxy vitamin D.sub.2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D.sub.2 which is converted in six steps to 1.alpha.,24(S)-dihydroxy vitamin D.sub.2. The syntheses also produced novel intermediates.

Methods for preparation and use of 1.alpha., 24(S) -dihydroxy vitamin D2

Methods for preparation and use of 1A,24(S)-dihydroxy vitamin D2

Methods for preparation and use of 1.alpha.,24(S)-dihydroxy vitamin D.sub.2

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Morton Grove, IL, United States of America

Sanjay K Singhal