Lupin, Inc.

Sanjay Chhagan Wagh

Himadri Sen

Makarand Krishnakumar Avachat

Bharat Raghunath Metkar

Hidaytulla Aga

Sachin Pundlik Kolhe

Subrata Kundu

A pharmaceutical suspension formulation comprising a dose greater than 100 mg/5 ml Cefixime and pharmaceutically acceptable excipients.

Pharmaceutical compositions of Cefixime

A chewable tablet comprising Cefixime having a mean particle size between 20&#x3bc; and 120&#x3bc; wherein the said composition demonstrates bioequivalence to a suspension of Cefixime trihydrate. The process of preparation of the chewable tablet comprises the steps of optionally micronizing Cefixime such that the mean particle size of the Cefixime particles is between 20&#x3bc; and 120&#x3bc;, blending with other excipients, roll compaction, milling to form granules, blending to form a secondary blend and compression of the secondary blend to form tablets.

Pharmaceutical formulation of cefixime for enhanced bioavailability

A stable taste masked, pharmaceutical composition comprising a plurality of coated, non-disintegrating discrete dosage units, said units comprising of a core comprising one or more cephalosporins such as cefuroxime axetil and cefpodoxime proxetil and one or more coating layers. Cefuroxime axetil is in &#x3b1;-crystalline and amorphous forms, where at least 30% of the Cefuroxime axetil is in the &#x3b1;-crystalline form, wherein the particle size distribution of the &#x3b1;-crystalline form being such that 100% of the particles have a particle size below 250&#x3bc;. The ratio of the crystalline fraction to the amorphous fraction ranges from 0.3:0.7 to 0.99:0.01. The particle size of cefpodoxime proxetil is such that 90% of the particles are below 15&#x3bc;. The process of preparation of coated, non-disintegrating pellets comprising the steps of reducing the particle size of the one or more cephalosporins, blending with the other excipients, wet granulation, extrusion, spheronization, drying and screening to obtain pellets, said pellets being further coated with one or more layers of film coating to achieve taste masking.

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Pune, India

Sanjay Chhagan Wagh