Chiral Quest, Inc.

Sanhui Lin

Jingyang Zhu

Wenge Li

Hui Lu

Xinjun Liu

Xiaojuan Zhang

Fei Xiong

Zijun Liu

Zhongwei Tian

A process for preparing an enantiomerically enriched cycloalkene-substituted alanine compound having the structure: by asymmetrically hydrogenating a dehydro amino acid compound having the structure: in a suitable reaction media in the presence of a catalyst having a transition metal moiety complexed to a chiral phosphine ligand to prepare enantiomerically enriched cycloalkene substituted alanine compounds having the structure of Formula (IA) or (IB), which are key intermediates for the ACE inhibitors ramipril and perindolpril: 

Enantioselective process for cycloalkenyl &#x3b2;-substituted alanines

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Suzhou, China

Sanhui Lin