D. R. Nano Co., Ltd.

Sangyoup Lee

Sehoon Kim

Ick Chan Kwon

The present invention discloses a method for diagnosing and detecting cancer by bioimaging using methylene blue nanoparticle as a contrasting agent. The methylene blue nanoparticle of the present invention for use as a topical cancer targeting phototherapeutic agent is composed of only a material of which the composition is clinically used or derived from human bodies, and thus a nanopreparation in which a barrier to clinical entry is low and the possibility of commercialization is very high, exhibits near-infrared fluorescence along with cancer targeting property, a capacity of generating a singlet oxygen and the like. Therefore, the methylene blue nanoparticle in the present invention is able to detect cancerous cells by emitting visible light in irradiation conditions.

Method of using methylene blue nanoparticle for detecting cancer by bioimaging

The present invention discloses a method for treating cancer disease by photodynamic therapy. The photodynamic therapy in the present invention uses a methylene blue nanoparticle as a therapeutic agent. The methylene blue nanoparticle of the present invention for use as a topical cancer targeting phototherapeutic agent is composed of only a material of which the composition is clinically used or derived from human bodies, and thus a nanopreparation in which a barrier to clinical entry is low and the possibility of commercialization is very high, exhibits near-infrared fluorescence along with cancer targeting property, capacity of generating a singlet oxygen and the like. Therefore, the methylene blue nanoparticle in the present invention is able to cure cancer cells by cell apoptosis in irradiation conditions.

Method for treating cancer by photodynamic therapy

The present invention relates to a methylene blue nanoparticle for bioimaging and photodynamic therapy, and a use thereof as a cancer therapeutic agent and a contrast agent. The methylene blue nanoparticle of the present invention for use as a topical cancer targeting photo therapeutic agent is composed of only a material of which the composition is clinically used or derived from human bodies, and thus a nanopreparation in which a barrier to clinical entry is low and the possibility of commercialization is very high, exhibits near-infrared fluorescence along with cancer targeting property, capacity of generating singlet oxygen and the like, and thus may be used for both bioimaging diagnosis such as optical imaging, and cancer targeting photodynamic therapy.

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Seoul, South Korea

Sangyoup Lee