University of California

Sangwei Lu

Fenyong Liu

Yong Bai

Hao Gong

Lee W Riley

Sheet of disposable drug formulation pouches

The present invention provides vectors, including a novel attenuated strain of, for efficient gene transfer into an animal, e.g. a mammalian host.

[object Object]

the Present Invention Provides Vectors, Including a Novel Attenuated Strain of, for Efficient Gene Transfer into an Animal, e.g. a Mammalian Host.

One aspect of the present invention relates to a nucleic acid construct which includes a first nucleic acid and a second nucleic acid operatively coupled to the first nucleic acid. The first nucleic acid molecule encodes a first peptide that has the sequence of InvX or another sequence incorporating the 58 amino acid cellular import region of Mce1A and confers onan ability to enter mammalian cells. The second nucleic acid molecule encoding a second peptide. Expression of the nucleic acid construct produces a fusion protein comprising the first peptide coupled to the second peptide. The second peptide may be a therapeutic or a diagnostic peptide. An alternative embodiment of the nucleic acid construct includes the first nucleic acid and an insertion site suitable for incorporation of the second nucleic acid molecule into this version of the construct. The present invention further relates to the fusion protein per se, screening methods for identifying fusion proteins having a protective effect against a pathogen, and therapeutic fusion proteins.

Growing community of inventors

Kensington, CA, United States of America

Sangwei Lu