Korea Research Institute of Bioscience and Biotechnology

Bionutrigen Co., Ltd.

Vspharmtech

Korea Institute of Bioscience and Biotechnology

Sangku Lee

Byoung-Mog Kwon

Dong Cho Han

Soo Hyun Kim

Kwang-Hee Son

Sei-Ryang Oh

Sang Han Lee

Doo-Young Kim

Jung Weon Lee

Tae Sook Jeong

Mun-Chual Rho

Jung-hee Kim

Joongku Lee

Jae Sun Moon

Sung Uk Kim

Hyeong-Kyu Lee

Sun Bok Jeon

Jiyoun Choi

Yu Jin Lee

Yae Jin Yoon

Jong Han Kim

Eui Il Hwang

Ju Ryoung Kim

Yangkyu Choi

Sung-Gyu Choi

Kyungseop Ahn

Ho-Jae Lee

Eun-Ah Kim

Soon-Ja Choi

Su-Yong Choi

Songhae Bok

Taesook Jeong

Euneai Kim

Surksik Moon

Myungsook Choi

Byunghwa Hyun

Chulho Lee

Gootaeg Oh

Mi-Young Lee

Jung-Hee Kim

The present invention relates to a pharmaceutical composition for preventing or treating cancer metastasis, a health functional food, and a method for preventing or treating cancer metastasis using the same, containing a novel compound for inhibiting migration and invasion of cancer cells or a pharmaceutically acceptable salt thereof as an active ingredient.

Inhibitors of cancer metastasis through inhibiting migration and invasion of cancer cells

The present invention relates to an anoikis-inducing agent comprising aextract, a tiarellic acid compound isolated therefrom or a pharmaceutically acceptable salt thereof, which is specific to cancer cells expressing a tumor-associated antigen L6 or a homolog thereof. Theextract, the tiarellic acid compound isolated therefrom or pharmaceutically acceptable salt thereof of the present invention leads to loss of cell adhesion to reduce cancer cell proliferation and exhibits the effect of inducing cell death in cancer cells expressing a tumor-associated antigen L6 or a homolog thereof, thereby being used for preventing and treating cancer diseases due to a tumor-associated antigen L6 or a homolog thereof.

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The present invention relates to a pharmaceutical composition and health food comprisingsp. PL3 extract or phellinsin A isolated from the same as an effective component. More particularly, the present invention relates to a pharmaceutical composition and health food comprisingsp. PL3 extract or phellinsin A isolated from the same as an effective component, wherein thesp. PL3 extract and its phellinsin A inhibit the oxidation of low density lipoprotein (LDL), and further, they can be used as a component for medicine and food to effectively prevent and treat cardiovascular diseases such as hyperlipemia and arteriosclerosis.

The present invention relates to phenolic acid derivatives of the formula I and compositions for the preventing and the treating blood lipid level-related diseases comprising the phenolic acid derivatives. The compounds have excellent effects of reducing blood lipid level, inhibiting cholesterol metabolism-related enzymes and preventing and treating blood lipid level-related diseases.

Phenolic acid derivatives and composition for preventing or treating blood lipid level-related diseases comprising the same

The present invention relates to cinnamaldehyde derivatives inhibiting growth of tumor cell and regulating cell cycle, the method for preparation and the pharmaceutical composition thereof. The cinnamaldehyde derivatives of the present invention can be effectively used as a cell cycle regulator or a cancer cell growth inhibitor, since it has an ability to regulate cell cycle by holding the cells in G2/M stage of the cell division and has activity to inhibit cancer cell growth.

Cinnamaldehyde derivatives inhibiting growth of tumor cell and regulating cell cycle, preparations and pharmaceutical compositions thereof

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Daejeon, South Korea

Sangku Lee