Snur & Db Foundation

Mitocon Ltd.

Seoul National University

The Catholic University of Korea Industry-academic Cooperation Foundation

University of Ulsan Foundation for Industry Cooperation

The Asan Foundation

Sanghee Kim

Hong-kyu Lee

Youngmi Kim Pak

James Jungho Pak

Taeho Lee

Tae-yoon Kim

Chang-Yuil Kang

Sang Kook Lee

Feng Li

Hyun-Jun Youn

Yoon-Sook Lee

Dong Jae Baek

Kyoo-A Lee

Shuai Yu

Minjae Cho

Eunhee Koh

Kiup Lee

Jedo Oh

Byung-Hak Kim

Daeduk Kim

The present invention relates to a S1PR4-targeting composition for preventing or treating non-alcoholic steatohepatitis and, more particularly, to a pharmaceutical composition and a health functional food composition, both comprising a sphingolipid compound which serves as a functional inhibitor against S1PR4, showing prophylaxis and therapy of non-alcoholic steatohepatitis. The sphingolipid compound of the present invention is expected to be applied as a leading material effective for the prevention or treatment of non-alcoholic steatohepatitis (NASH) as it has the effect of reducing the infiltration of inflammatory cells into hepatic tissues and suppressing fibrosis and decreases a level of liver injury (ALT), inflammation in hepatic tissues, the expression of a fibrosis-related gene.

S1PR4-targeting composition for preventing or treating non-alcoholic steatohepatitis

An alkaloid derivative having an activity of inhibiting angiogenesis and having structural stability is disclosed. A pharmaceutical composition containing the alkaloid derivative and its use are disclosed. The alkaloid derivative can be effectively used for treating or preventing diabetic retinopathy, cancer, duodenal ulcer, arthritis or obesity.

Alkaloid derivative having angiogenesis inhibitory effect, and pharmaceutical composition containing same

A phytosphingosine derivative of chemical formula IA or IB, and a composition comprising the phytosphingosine derivative for preventing and treating inflammatory skin diseases, autoimmune diseases, and hyperkeratotic diseases. The phytosphingosine derivatives of the present disclosure are involved with transcription factors related to inflammation, autoimmune diseases and hyperkeratotic diseases, the expression and the generation of inflammatory mediators, signal transduction mechanisms, and the expression and the activity of relevant enzymes and the like.

Phytosphingosine derivatives, and composition comprising same for preventing and treating inflammatory skin diseases, autoimmune diseases, and hyperkeratosis diseases

Disclosed are novel &#x3b1;-galactosylceramide derivatives, pharmaceutically acceptable salts thereof, preparation methods thereof, and pharmaceutical compositions for use in an immune adjuvant containing the same as an active ingredient. The derivatives, in which the amide moiety of &#x3b1;-GalCer is bioisosterically replaced with a triazole moiety, direct cytokine secretion toward IL-4 rather than IFN-&#x3b3;and thus can be used as a therapeutic for autoimmune diseases regulated by IL-4, such as type 1 diabetes and multiple sclerosis.

&#x3b1;-galactosylceramide derivatives, pharmaceutically acceptable salts thereof, preparation method and pharmaceutical composition for the immune adjuvant containing the same as an active ingredient

The present invention relates to the compound of formula (I) useful as an intercalator in electrochemical detection of double-stranded DNAs, and a method for preparation thereof:

Intercalator suitable for electrochemical detection of double strand DNAs and a process for preparing thereof

Described in the present invention are a highly sensitive method for electrochemically detecting a DNA using a novel mixed intercalator and a detection kit useful for practicing said method.

Mixed intercalator and electrochemical detection of DNA using same

Growing community of inventors

Seoul, South Korea

Sanghee Kim