Nanostring Technologies, Inc.

Koninklijke Philips Corporation N.v.

Bruker Spatial Biology, Inc.

Sanghamithra Korukonda

Joseph M Beechem

Dwayne L Dunaway

Rustem Khafizov

Margaret Hoang

Mark Gregory

Dae Kim

Elizabeth A Manrao

Yi Deng

Emil George Radulescu

Jean-luc Robert

Mark McElwain

Peter Skene

Cassandra Burke

Gavin Meredith

Francois Guy Gerard Marie Vignon

Ameet Kumar Jain

Richard Allen Snyder

Matthew J Walsh

Matthew Walsh

An acoustically registerable probe includes a transducer () to generate acoustic pulses, and a beamformer () coupled to the transducer to adjust a field of view of the acoustic pulses. The transducer is configured to iteratively send and receive acoustic energy with a decremented field of view angles to identify a position of the transducer () to other transducers and to reveal positions of the other transducers to the transducer through a medium carrying the acoustic pulses to register the transducer to the other transducers coupled to the medium.

Acoustic registration of internal and external ultrasound probes

The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.

Chemical compositions and methods of using same

In some embodiments, ultrasound receive beamforming yields beamformed samples, based upon which spatially intermediate pixels () are dynamically reconstructed. The samples have been correspondingly derived from acquisition through respectively different acoustic windows (). The reconstructing is further based on temporal weighting of the samples. In some embodiments, the sampling is via synchronized ultrasound phased-array data acquisition from a pair of side-by-side, spaced apart () acoustic windows respectively facing opposite sides of a central region () to be imaged. In particular, the pair is used interleavingly to dynamically scan jointly in a single lateral direction in imaging the region. The acquisition in the scan is, along a synchronization line () extending laterally across the region, monotonically progressive in that direction. Rotational scans respectively from the window pair are synchronizable into a composite scan of a moving object. The synchronization line () can be defined by the focuses of the transmits. The progression may strictly increase.

Synchronized phased array data acquisition from multiple acoustic windows

Depiction, within a single imaging modality, of an intervention device and body tissue surrounding the device, is improved by interrogating a subject that includes the intervention device and the tissue. An image is created using, for a parameter, a value, of the parameter (), better suited to one or the other of a device region depicting the intervention device and a tissue region depicting the tissue. The value is used to yield respectively either a first image () or a second image (). Respective presets may correspondingly have different values for the parameter. From jointly the first image and the second image which are both of the single modality, a combination is formed that is an image of the intervention device depicted as surrounded by the tissue. The combinations may be formed dynamically and ongoingly. An apparatus for the improved depiction may be configured for the use of the parameter in a stage prior to image processing conducted on a scan-converted image () if such image processing is employed.

Single-modality-based visual distinguishing of medical intervention device from tissue

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Seattle, WA, United States of America

Sanghamithra Korukonda