The Feinstein Institutes for Medical Research

The Feinstein Institute for Medical Research

Sangeeta S Chavan

Kevin J Tracey

Valentin A Pavlov

Adam M Kressel

Chad Edward Bouton

William Hanes

Todd Levy

Theodoros Zanos

Jian Hua Li

Andrew Stiegler

Harold Silverman

Emily Battinelli

Compositions and methods are provided comprising choline acetyltransferase (ChAT) and PEGylated ChAT for treating hypertension.

Choline acetyltransferase as a therapy for hypertension

The present disclosure relates to systems, methods and devices to monitor, diagnose and/or treat diseases or disorders comprising a calibration phase and a real-time diagnostic, treatment or monitoring phase, the calibration phase correlating a plurality of nerve activity measurements from a chronically implanted electrode in a subject with a plurality of concurrent measurements of levels of cytokines and/or glucose in the blood to obtain a functional relationship between blood cytokine and/or glucose levels and vagus nerve activity, and the diagnostic, treatment or monitoring phase analyzing the subject's real-time vagus nerve activity in accordance with the previously obtained functional relationship to initiate a treatment method.

Systems and methods for real-time monitoring of physiological biomarkers through nerve signals and uses thereof

Methods for electrical modulation of inflammation or serum TNF levels in a subject.

Treatment of inflammation by selective DMV cholinergic neuron stimulation

Methods are disclosed for treating a subject having a disease or disorder comprising stimulating a nerve of the subject with a corrective stimulus pattern derived from a disease-specific, condition-specific, endogenous mediator-specific or pharmacologic agent-specific neurogram in an amount and manner effective to treat the disease or disorder.

Nerve stimulation for treatment of diseases and disorders

Methods are disclosed for treating a subject having a disease or disorder comprising providing the subject with an acoustic energy stimulus derived from a disease-specific, condition-specific, endogenous mediator-specific or pharmacologic agent-specific neurogram in an amount and manner effective to treat the disease or disorder.

Bioelectronic pharmaceuticals

Methods are disclosed for preventing systemic infection or controlling metastases or providing a vaccine adjuvant in a subject, the methods comprising stimulating one or more peripheral nerves innervating one or more lymph nodes of the subject.

Lymphatic system neuromodulation and uses thereof

The present invention provides methods of treating inflammatory diseases in a subject comprising administering to the subject a therapeutically effective amount of an agent that inhibits pigment epithelium-derived factor (PEDF) and methods of screening for agents that inhibit PEDF.

Growing community of inventors

Syosset, NY, United States of America

Sangeeta S Chavan