Lg Chem, Ltd

Lg Life Sciences, Limited

Sang Yong Hong

Ji Young Kim

Hye Jin Kim

Jong Sung Koh

Chang-Seok Lee

Hee Han

Sung Bae Lee

Min-Jung Kim

Ki Dong Koo

Seung Yup Paek

Hyeon Joo Yim

Sung Ho Kim

Sungsub Kim

Deok Seong Park

Geun Tae Kim

Kyoung-Hee Kim

Suk Jun Youn

Oh Hwan Kwon

Zi-Ho Yeom

Dong-Jun Yeo

Gwong-Cheung Hur

Seong Cheol Bu

Dongchul Lim

Hee Oon Han

The present invention relates to a novel compound represented by Formula 1, functioning as a sphingosine-1-phosphate receptor agonist useful for treating autoimmune disorders, a preparation method therefor, a pharmaceutical composition containing the same as an active ingredient, and a use. The compound according to the present invention has an effect in extensive autoimmune diseases and chronic inflammatory diseases, including relapsing-remitting multiple sclerosis, and can also be used for treating or preventing immunoregulatory disorders.

Sphingosine-1-phosphate receptor agonist, preparation method therefor, and pharmaceutical composition containing same as active ingredient

The present invention relates to a compound of Formula 1, a pharmaceutically acceptable salt or isomer thereof, a pharmaceutical composition including the same, and a use. The compound of Formula 1 according to the present invention has ketohexokinase (KHK) inhibitory activity, and is effectively used for preventing or treating metabolic disease such as diabetes, diabetic complications, obesity, nonalcoholic fatty liver disease, and fatty hepatitis.

3-azabicyclo[3,1,1]heptane derivative and pharmaceutical composition including same

Novel compounds exhibiting good inhibitory activity versus Dipeptidyl Peptidase-IV(DPP-IV) include those of the following formula (1) or pharmaceutically acceptable salt thereof: wherein A is a substituted or unsubstituted 1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridine, 5,6 -dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine, 4,5-dihydro-7H-isooxazolo[3,4-c]pyridine, 3,4 -dihydroisoquinoline, 5,8-dihydropyrido[3,4-d]pyrimidine, or 6,7 -dihydro[1,3]thiazolo[4,5,c]pyridine, and B is a substituted or unsubstituted piperidin-2-one, morpholin-3-one, oxazolidin-2-one, pyrrolidin-2-one, or 1,5-dihydro-pyrrol-2-one. Methods of preparing the novel inhibitory compounds of formula (1) and pharmaceutical compositions containing the same as an active agent are disclosed.

Dipeptidyl Peptidase-IV inhibiting compounds, method of preparing the same, and pharmaceutical compositions containing the same as an active agent

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Daejeon, South Korea

Sang Yong Hong