Samsung Electronics Co., Ltd.

Korea Advanced Institute of Science and Technology

Sang Yeul Han

Kyung Eun Kim

Hyo Seon Lee

Kwang Hoon Lee

Hyung-Chan Kim

Seok Kyun Kim

Seung Ja Oh

Yoon Sook Lee

Yong In Kim

Chung Ho Kim

Seung Hyun Lee

Su Jin Kim

Sunghyun Kim

Chan Kim

Gou Young Koh

Kwang-Hoon Lee

An anti-Ang2 antibody or an antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang2) and complexes with a Tie2 receptor and Ang2, and related methods and compositions.

Anti-ANG2 antibody

An anti-Ang2 antibody or an antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang2) and complexes with a Tie2 receptor through Ang2, and methods of using the same.

Humanized or affinity-matured anti ang-2 antibody and uses thereof

A fusion polypeptide capable of binding simultaneously to angiopoietin 2, VEGF-C and VEGF-D; or capable of binding simultaneously to VEGF-C and VEGF-D, and methods for the preparation and use thereof.

Fusion polypeptide capable of binding simultaneously to VEGF-C and VEGF-D

An Ang2 specific antibody, a method of inhibiting angiogenesis or a method of treating a disease related to the activation and/or overproduction of Ang2 using the antibody, and a composition for diagnosing a disease related to the activation and/or overproduction of Ang2 including the antibody.

Angiopoietin-2 specific antibodies and uses thereof

Humanized or affinity-matured anti Ang-2 antibody and uses thereof

A method for the prevention and/or treatment of a disease accompanied by vascular leakage and/or vascular inflammation comprising administering an anti-Ang2 antibody or an antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang2) and forms a complex with a Tie2 receptor and Ang2.

Method of blocking vascular leakage using an anti-ANG2 antibody

Anti-Ang2 antibody

Fusion polypeptide inhibiting VEGF-C, VEGF-D and/or angiopoietin-2, and use thereof

An Ang2 specific antibody, a method of preventing and/or treating a disease related to the activation and/or overproduction (overexpression) of Ang2 by administering the antibody to a subject, and a method of screening a candidate substance for diagnosing, preventing, or treating a disease related to activation or overproduction of Ang2.

Antibody specifically binding to ANG2 and use thereof

An antibody or antigen-binding fragment thereof that specifically binds to and inhibits VEGF-C and uses thereof in a method of inhibiting angiogenesis and a method of preventing, treating, and/or diagnosing a disease associated with activation and/or overexpression of VEGF-C, using the antibody, and a method of detecting the presence of VEGF-C in a sample.

Antibodies or antigen-binding fragments thereof specifically binding to VEGF-C and use thereof

Provided are an anti-Ang-2 antibody or antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang-2), related compositions and pharmaceutical compositions, and methods for using such compositions and pharmaceutical compositions.

Ang-2 specific antibodies and uses thereof

A method of preventing or treating cancer using an anti-Ang2 antibody or an antigen-binding fragment thereof that specifically binds to an angiogenesis-inducing factor Angiopoietin-2 (Ang2) and complexes to a Tie2 receptor while bound with Ang2.

Use of an anti-Ang2 antibody

There are provided an angiopoietin-2 (Ang2) derived peptides, polypeptides, and peptide complexes, and a method for inhibition of binding between Ang2 and integrin and prevention and/or treatment of a disease caused by the activation of Ang2 or the binding between Ang2 and integrin using the peptide, polypeptides, and peptide complexes.

Growing community of inventors

Yongin-si, South Korea

Sang Yeul Han