Nitto-denko Corporation

Annam Biosciences, LLC

Sang Van

Lei Yu

Gang Zhao

Xiaoli Fu

Shouping Ji

Xinghe Wang

Zhongling Feng

Yasunobu Tanaka

Zheng Hou

Jiadong Zhou

Yucheng Song

Kenji Matsumoto

Nitnara Viroonchatapan

Yoshiro Niitsu

Sheng Li

Peng Wang

Yi Jin

Jian Liu

J Kevin Cammack

Hyun Sik Chae

Chris Castell

Nianchun Ma

Fu Chen

Sanjib Kumar Das

Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications.

Polyglutamate-amino acid conjugates and methods

Asymmetrical dendritic compound of the Formula (I) as described herein can contain multiple functional moieties as represented by Rand Rin Formula (I). In various embodiments, the functional moieties include N-Boc, a targeting ligand, a drug, and/or an imaging agent. A number of such functionalized asymmetrical dendritic compounds can be used for various therapies, including cancer treatment.

N-BOC-dendrimers and their conjugates

Degradable complexes comprising a polycation, a polyanion and a polynucleotide are useful for in vivo polynucleotide delivery applications.

Biodegradable polyacetals for in vivo polynucleotide delivery

Various compositions that include a hydrophobic compound and a polyamino acid conjugate are prepared. The compositions described herein are useful for a variety of drug, biomolecule, and imaging agent delivery applications.

Compositions that include a hydrophobic compound and a polyamino acid conjugate

Polymers and methods of making them are described. The polymers may be used to coat living cells. The polymer-coated cells are useful in cell therapy applications.

Polymer coating of cells

Compositions that can include a cationic polymeric carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a target organ or tissue or inhibiting the growth of a cancer cell.

Drug carriers

Condensation polymerization methods are used to prepare various biodegradable polyacetals of the general formula (I). Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications. 

Biodegradable polyacetals and methods

Complexes are disclosed which are a combination of a polynucleotide and a biodegradable polyacetal-peptide. The disclosed complexes are useful for cell transfection.

Compositions and methods for biodegradable polymer-peptide mediated transfection

A microscope system, kit and method are described for observation of cellular activity in real time. The system is used to monitor cell transfection using a polynucleotide noncovalently attached to a carrier, The carrier labeled with a dye or fluorescent agent so that transport of complex can be monitored in real time. The polynucleotide includes both a gene of interest and a reporter gene. The reporter gene indicates successful expression of the gene of interest.

Microscope system and methods for intracellular studies

The present invention provides visible light sensitive and ultraviolet (UV) light sensitive composition for DNA transfer comprising acid sensitive polyacetals developed as DNA/RNA delivery agents, a photoacid generator and optionally a photosensitizer.

Photocleavable DNA transfer agent

A synthetic polymer comprises a cationic recurring unit and a crosslinking unit, wherein the crosslinking unit comprises at least a first degradable unit (preferably acid-labile) and at least a second degradable unit (preferably hydrolyzable). A carrier composition comprising the synthetic polymer and a bioactive agent is useful for the delivery of the bioactive agent into the nuclei of the cells.

Cationic polymers having degradable crosslinks

Polyacetals comprising a recurring units represented by a formula selected from the group consisting of formula (I) and (II):

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San Diego, CA, United States of America

Sang Van