Illumina Corporation

Illumina Cambridge Limited

Sang Ryul Park

M Shane Bowen

Maria Candelaria Rogert Bacigalupo

John M Beierle

James M Tsay

Ludovic Vincent

Kevin L Gunderson

Kandaswamy Vijayan

Yir-Shyuan Wu

Shengrong Lin

Bala Murali Venkatesan

Lorenzo Berti

Boyan Boyanov

Andrew Antony Brown

Wayne N George

Jeffrey S Fisher

Lewis J Kraft

Brian Douglas Mather

Justin Fullerton

Sahngki Hong

David Louis Heiner

Alexandre Richez

Sean M Ramirez

Kevan Samiee

Peyton Shieh

Anmiv Prabhu

Scott William Bailey

Tyler Jamison Dill

Wei Wei

Edwin Li

Robert Yang

Yuxiang Huang

Naiqian Zhan

Valerie Uzzell

Sunmin Ahn

Samantha Schmitt

Leonid Malevanchik

Kristina Munoz

Jung-Huei Peng

Shang-Ying Tsai

Dajun Yuan

Li-Min Hung

Hui Han

Danny Yuan Chan

Shane Bowen

James Tsay

Maria Candelaria Bacigalupo

Shane M Bowen

An example of a flow cell includes a substrate; a first primer set attached to a first region on the substrate, the first primer set including an un-cleavable first primer and a cleavable second primer; and a second primer set attached to a second region on the substrate, the second primer set including a cleavable first primer and an un-cleavable second primer.

Flow cells

A flow cell package includes first and second surface-modified patterned wafers and a spacer layer. The first surface-modified patterned wafer includes first depressions separated by first interstitial regions, a first functionalized molecule bound to a first silane or silane derivative in at least some of the first depressions, and a first primer grafted to the first functionalized molecule in the at least some of the first depressions. The second surface-modified patterned wafer includes second depressions separated by second interstitial regions, a second functionalized molecule bound to a second silane or silane derivative in at least some of the second depressions, and a second primer grafted to the second functionalized molecule in the at least some of the second depressions. The spacer layer bonds at least some first interstitial regions to at least some second interstitial regions, and at least partially defines respective fluidic chambers of the flow cell package.

Flow cell package and method for making the same

A method includes forming a patterned substrate including a plurality of base pads, using a nano-imprint lithography process. A capture substance is attached to each of the plurality of base pads, optionally through a linker, the capture substance being adapted to promote capture of a target molecule.

Microarray fabrication system and method

A flow cell includes: a first substrate; a second substrate; a first resin layer disposed over an inner surface of the first substrate; a second resin layer disposed over an inner surface of the second substrate; a first plurality of biological capture sites located at the first resin layer; a second plurality of biological capture sites located at the second resin layer; and a polymer layer interposed between the first resin layer and the second resin layer, such that the first substrate is attached to the second substrate via at least the first resin layer, the polymer layer, and the second resin layer, wherein the polymer layer defines a plurality of microfluidic channels that extend through polymer layer.

Method to produce chemical pattern in micro-fluidic structure

A microarray is designed capture one or more molecules of interest at each of a plurality of sites on a substrate. The sites comprise base pads, such as polymer base pads, that promote the attachment of the molecules at the sites. The microarray may be made by one or more patterning techniques to create a layout of base pads in a desired pattern. Further, the microarrays may include features to encourage clonality at the sites.

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Sang Ryul Park