Boryung Pharmaceutical Co., Ltd.

Sang-Lin Kim

Hyun-Kwang Tan

Ji-han Kim

Hahn-Sun Jung

Seung-Hoon Kang

Dong-Il Kim

Byoung-wug Yoo

Jae-hyoung Lee

Sang-Min Lim

Jun-Sik Kim

Ho-Beom Lee

Geun-Hong Min

Jae-seog Kang

Cheon-Ik Park

Kyung-jin Jang

Wuk-Sang Ryu

Hae-Won Ryou

Jung-Bok Lee

Song-Jae Lee

Byoung-Wug Yoo

Ji-Han Kim

Provided is a method for producing a target protein via cultivation of transgenic plant cells comprising a promoter capable of expressing the protein under sugar-free conditions in the response to the depletion of sugar and a gene encoding the target protein, without exchange of a cell growth medium with a sugar-depleted medium comprising the addition of an amino acid mixture to the sugar-rich medium used to grow the plant cells.

Method for producing target proteins using amino acids and pyruvic acids in culture of plant cells

An antibacterial composition for external application, particularly, a remedial formulation for external use containing fluconazole is disclosed. The formulation comprises a base material, 0.1-5.0 percent by weight of fluconazole and 1.0-40.0 percent by weight of any one compound selected from a group consisting of fatty acid, fatty alcohol, higher fatty acid ester and lower alcohol based on weight of the base material. The composition according to the present invention has various advantages of a favorable absorption into a system through the skin of a human body and delivery of active material into horny layer of the skin, a reduced skin stimulation and an excellent stability. Therefore, the composition is efficiently useable in a medical treatment application for dermatomycosis-related infectious diseases including tinea pedis, tinea corporis, tinea cruris, tinea versicolor and/or candidiasis and the like.

Antifungal remedy formulation for external application

A process for preparing pyrimidinone compound and salts thereof The method of the present invention enables the convenience to produce the pyrimidinone derivatives in high yields, which pyrimidinone compounds are useful for treating cardiovascular diseases caused by binding angiotensin II to its receptors, through antagonistic activity against angiotensin II receptors.

Method for preparing pyrimidinone compound and pharmaceutically acceptable salts thereof

The present invention relates to a novel pyrimidinone compounds and the pharmaceutical acceptable salts thereof having remarkable antagonistic action against angiotensin II receptor, thereby, being useful in treating cardiovascular disease caused by binding angiotensin II to its receptor.

Pyrimidinone compounds, pharmaceutical compositions containing the compounds and the process for preparing the same

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Seoul, South Korea

Sang-Lin Kim