The Brigham and Women's Hospital, Inc.

Massachusetts Eye and Ear Infirmary

Gs Caltex Corporation

Sang-Jun Jeon

Gregory D Cuny

Lixin Qiao

Albert Edge

Marcie A Glicksman

Kathleen Seyb

Sang-Hyun Lee

Jung-Hee Cho

Moon-Ho Eom

Julia Lee

Jin Dal Rae Choi

This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a biological cell. More specifically, the invention relates to the treatment of diseases and/or disorders that would benefit from increased Atoh1 expression, e.g., a hearing impairment or imbalance disorder associated with a loss of auditory hair cells, or a disorder associated with abnormal cellular proliferation.

Compounds that enhance Atoh1 expression

The present invention relates to an apparatus and a method for fermenting, separating, and refining a product, which is produced by cultivating a microorganism. The apparatus and the method for fermenting, separating, and refining, of the present invention, can separate and refine the product that is produced by microbial fermentation in a simple, continuous manner and with high efficiency.

Apparatus and method for separating and refining product manufactured by microbial fermentation by using adsorbent

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Seoul, South Korea

Sang-Jun Jeon