Sk Innovation Co., Ltd.

Sk Holdings Co., Ltd.

Sang-Il Lee

Ji-Hoon Lee

Byong-Sung Kwak

Jong-Ho Lim

Young-Eun Cheon

Hee-Jun Hwang

Yeon-Ho Kim

The present disclosure relates to a method for preparing a mordenite zeolite, the method including crystallizing, at a temperature of 150° C. to 190° C., a gel which includes, in mol based on 1 mol of silica, 0.02 to 0.2 of an alumina precursor, 0.01 to 0.04 of a structure-directing agent, 0.1 to 0.18 of a pH control agent, and 10 to 100 of water. According to the present disclosure, a mordenite zeolite having high particle size uniformity and a particle size controllable while maintaining the particle size uniformity may be prepared.

Method for preparing mordenite zeolite having controllable particle size

Disclosed is a process for the preparation of 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)-dibenzo[b,f][1,4]thiazepine. In the process, low-priced 2,2'-dithiosalicylic acid as starting material is subjected to bond formation reaction with 1-chloro-2-nitrobenzene in a basic aqueous solution, a nitro group reduction reaction is conducted, cyclization and chlorination reactions are simultaneously carried out in the presence of a equivalent amount of halogenating agent, a reaction with piperazine is continuously conducted without separation, and a reaction with 2-haloethoxyethanol is conducted, thereby it is possible to economically producing Quetiapine, that is, 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)-dibenzo[b,f][1,4]thiazepine, in an environmentally friendly manner. Particularly, the process is advantageous in that economic efficiency is assured because of use of the low-priced starting material, use of an organic solvent is minimized because a reaction is conducted in an aqueous solution, and it is possible to achieve the environmentally friendly and economical process having high commercial usefulness because the number of reaction steps of the process is reduced and because generation of acidic waste is minimized.

Process for the preparation of 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)dibenzo[b,f][1,4]thiazepine

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Daejeon, South Korea

Sang-Il Lee