Alteogen, Inc.

Sang Hoon Yun

Soon Jae Park

Ji-Sun Kim

Minsoo Byun

Sun-Ah You

Hyung-Nam Song

Jeong Soo Cho

Kibum Park

Jaehyeong Ko

Kyuwan Kim

Ki Seok Nam

Disclosed is a method for producing hyaluronidase or a variant thereof. Specifically, the method is capable of changing the N-glycan levels under culture conditions including a controlled concentration of glucose in the culture medium and a decreased culture temperature for a specific culture time period, thereby increasing the specific activity by 10% or more and improving the quality and production yield.

Method for producing recombinant hyaluronidase

The present invention relates to a growth hormone receptor antagonist comprising a growth hormone variant which is modified by substitution of one or more amino acids of growth hormone. Further, the growth hormone receptor antagonist of the present invention may further comprise a long-acting carrier which is fused to the growth hormone variant. The growth hormone receptor antagonist may have strong binding potency to growth hormone receptor and may exhibit a long-lasting antagonistic action.

Growth hormone receptor antagonists and fusion proteins thereof

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Daejeon, South Korea

Sang Hoon Yun