Kyungpook National University Industry-academic Cooperation Foundation

Daegu Gyeongbuk Institute of Science and Technology

Sang Hee Shin

Suyeon Ryu

In Seong Jung

Do Kyung Jung

Moon-Chang Baek

Kyungmoo Yea

The present invention relates to a composition, for prevention or treatment of cancer diseases, comprising CD8+ T cells activated by CD4+ T cell-derived extracellular vesicles as an active ingredient. It was found that the secretion of extracellular vesicles from cytokine-activated CD4+ T cells increases and the extracellular vesicles enhance proliferation and activity of CD8+ T cells to induce the death of cancer cells, thereby augmenting an anticancer effect. Thus, the present invention provides the CD8+ T cells activated by CD4+ T cell-derived extracellular vesicles as a pharmaceutical agent or an immunotherapeutic agent for cancer diseases, and a method for activating CD8+ T cells by using CD4+ T cell-derived extracellular vesicles to prepare CD8+ T cells showing excellent anticancer activity as described above.

Composition, for prevention or treatment of cancer disease, comprising cytotoxic T cells activated by T helper cell-derived extracellular vesicles as active ingredient

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Busan, South Korea

Sang Hee Shin