Case Western Reserve University

The University of Texas System

Other

The Brigham and Women's Hospital, Inc.

University of Kentucky Research Foundation

Medical College of Ohio

Rodeo Therapeutics Corporation

Johns Hopkins University

Sanford D Markowitz

Bert Vogelstein

Kenneth W Kinzler

Nickolas Papadopoulos

Joseph Ready

Joseph Willis

Amitabh Chak

Amar Desai

Stanton L Gerson

Monika Antczak

Bruce Posner

Helen Moinova

James K V Willson

Rom Leidner

Dennis Siedlak

Michael G Brattain

KiBeom Bae

Dean J Secrest

Jeffrey Silver Taggart

Hsin-Hsiung Tai

Bin Hu

Michael P Boutillette

Meng Li

Luis Diaz

Yongyou Zhang

Sung Yeun Yang

Won Jin Ho

William Greenlee

Monica Bertagnolli

Yiyuan Yuan

Thomas LaFramboise

Rebecca L Blice

Richard Yazbeck

Jean-Pierre J Issa

Melissa Moss

William Grady

James K Willson

Lishan Aklog

Noelle Williams

Mukesh K Jain

Vinay Varadan

Osamu Maeda

Rebecca Blice

Youngyou Zhang

Stephen L Gwaltney

Dawn Dawson

Stephen P Fink

James Kv Wilson

Mohamed Sabeh

Lois Myeroff

Wei-Dong Chen

James KV Willson

Bruce A Posner

Kibeom Bae

The disclosure provides methods for storage solutions for preserving DNA methylation patterns over a period of time. The disclosure also provides for methods of using methylated DNA stored in such storage solutions.

Compositions and methods for preserving DNA methylation

A device for collecting a biological sample in a patient includes a collection portion having a first axial end portion and a second axial end portion. The second axial end portion has a collapsed position and an expanded position. The second axial end portion moves in an axial direction relative to the first axial end portion when the second axial end portion moves between the collapsed position and the expanded position. The second axial end portion extends axially into the first axial end portion and has a concave shape when in the collapsed position. The second axial end portion is convex when in the expanded position.

Device for collecting a biological sample

Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.

Compositions and methods of modulating short-chain dehydrogenase activity

A device for collecting a biological sample in a subject, the device including an inflatable portion attached to a tubular member, and designed to expand from within the tubular member when inflated and to retract within the tubular member, a surface on the inflatable portion provided with varied thickness to facilitate movement of the inflatable portion between an expanded state and a retracted state, and a plurality of projections on the surface to allow collection of the biological sample when the inflatable portion is in the expanded state.

Device for biological cell collection and method of use

The disclosure provides methods for identifying genomic loci (e.g., vimentin and/or SqBE18) that are differentially methylated in metaplasias (e.g., Barrett's esophagus) and/or neoplastic cancers (e.g., esophageal cancers). Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal metaplasias and/or neoplasias.

Methods and compositions for detecting esophageal neoplasias and/or metaplasias in the esophagus

Compositions and methods of modulating short-chain dehydrogenase

A method of treating intestinal gastrointestinal, or bowel disorders in a subject in need thereof includes administering to the subject a therapeutically effective amount of 15-PGDH inhibitor alone or in combination with a corticosteroid and/or TNF alpha antagonist.

Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof

A method of treating preventing, minimizing, and/or reversing congestive heart failure, cardiomyopathy, and/or reduction of cardiac ejection fraction in a subject in need thereof includes administering to the subject a therapeutically effective amount of a 15-PGDH inhibitor.

Inhibitors of short-chain dehydrogenase activity for treating coronary disorders

This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as neoplasia of the upper or lower gastrointestinal tract, pancreas, and/or bladder.

Methods and compositions for detecting gastrointestinal and other cancers

A method of treating or preventing a fibrotic disease, disorder or condition includes administering to a subject in need of treatment a 15-PGDH inhibitor.

Inhibitors of short-chain dehydrogenase activity for treating fibrosis

A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.

Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis

Growing community of inventors

Pepper Pike, OH, United States of America

Sanford D Markowitz