Aligos Therapeutics, Inc.

Tibotec Pharmaceuticals Ltd.

Sandrine Vendeville

Pierre Jean-Marie Bernard Raboisson

Yannick Debing

Leonid Beigelman

David Bernard Smith

David Craig McGowan

Vladimir Serebryany

Herman Augustinus De Kock

Wim Gaston Verschueren

Dominique Louis Nestor Ghislain Surleraux

Piet Tom Bert Paul Wigerinck

Antitsa Dimitrova Stoycheva

Samuel Leo Christiaan Moors

Jan Octaaf Antoon De Kerpel

Marieke Christiane Johanna Voets

David Mcgowan

Daniel Getman

Marie-Pierre De Bethune

Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Bicyclic compounds

Substituted imidazo[1,5-a]pyrazines for the treatment of hepatitis B

Tricyclic compounds

Pyrrole compounds

Bicyclic and tricyclic compounds

Heterocyclic compounds

The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein Rand Reach are H, optionally substituted Calkyl, Calkenyl, Ccycloalkyl, aryl, Het, Het; Rmay also be a radical of formula (RR)NC(RR)CR&#x2014;; t is 0, 1 or 2; Ris H or Calkyl; L is &#x2014;C(&#x2550;O)&#x2014;, &#x2014;O&#x2014;C(&#x2550;O)&#x2014;, &#x2014;NR&#x2014;C(&#x2550;O)&#x2014;, &#x2014;O&#x2014;Calkanediyl-C(&#x2550;O)&#x2014;, &#x2014;NR&#x2014;Calkanediyl-C(&#x2550;O)&#x2014;, &#x2014;S(&#x2550;O)&#x2014;, &#x2014;O&#x2014;S(&#x2550;O)&#x2014;, &#x2014;NR&#x2014;S(&#x2550;O); Ris Calkyl, aryl, Ccycloalkyl, CcycloalkylCalkyl, or arylCalkyl; Ris H, CalkylOC(&#x2550;O), carboxyl, aminoC(&#x2550;O), mono- or di(Calkyl)aminoC(&#x2550;O), Ccycloalkyl, Calkenyl, Calkynyl or optionally substituted Calkyl; A is Calkanediyl, &#x2014;C(&#x2550;O)&#x2014;, &#x2014;C(&#x2550;S)&#x2014;, &#x2014;S(&#x2550;O)&#x2014;, Calkanediyl-C(&#x2550;O)&#x2014;, Calkanediyl-C(&#x2550;S)&#x2014; or Calkanediyl-S(&#x2550;O)&#x2014;; Ris H, OH, Calkyl, HetCalkyl, HetCalkyl, optionally substituted aminoCalkyl; Ris CalkylO, Het, HetO, Het, HetO, aryl, arylO, Calkyloxycarbonylamino or amino; and in case &#x2014;A&#x2014; is other than Calkanediyl then Rmay also be Calkyl, HetCalkyl, HetOCalkyl, HetCalkyl, HetOCalkyl, arylCalkyl, arylOCalkyl or aminoCalkyl; whereby each of the amino groups in the definition of Rmay optionally be substituted; Rand &#x2014;A&#x2014;Rtaken together with the nitrogen atom to which they are attached may also form Hetor Het. It further relates to their use as broadspectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. It also concerns combinations thereof with another anti-retroviral agent, and to their use in assays as reference compounds or as reagents.

Broad spectrum 2-(substituted-amino)-benzothiazole sulfonamide HIV protease inhibitors

Growing community of inventors

Brussels, Belgium

Sandrine Vendeville