Philip Morris Products S.a.

Sandrine Roesti

Karen Oishi

Oleg Mironov

Yorick Klipfel

Shunhong Dai

Prisca Campanoni

John Faulkner

Andrea Carraro

Helene Laparra

Rosa Cabrera

Nicolas Lugon-Moulin

Gustavo Ramirez

Julien Beuchat

Claudio Facchinetti

Richard Mundell

Anne Mc Govern

The present invention relates to protein expression in plants, particularly the large-scale production of recombinant polypeptides in wholeplants. The use of preselected combination ofvarieties andstrains, optionally including one or more improvements to the transient expression-based methods of the invention, enables the production of large quantities of a heterologous polypeptides economically and in a short period of time.

Protein expression in plants

The present invention relates to methods for expressing proteins of interest, particularly pharmaceutically valuable proteins, transiently in plants. In particular, the invention provides an improved method for introducingcells into a whole plant or a plant organ. The methods of the invention provides efficient agroinfiltration of many plants singly or simultaneously resulting in a yield of recombinant proteins that is higher than that obtained by other methods. The methods can be readily scaled and automated to meet changing demands of the recombinant protein.

Methods for producing proteins in plants

Growing community of inventors

Grandson, Switzerland

Sandrine Roesti