Lion Bioscience Ag

Other

Advanced Tissue Sciences, Inc.

Sandra R Slivka

Beverly E Girten

John S Kiely

Timothy Gahman

Michael C Griffith

Amaresh Basu

Curtis C Hecht

Yazhong Pei

Ronald R Tuttle

Hengyuan Lang

Lee K Landeen

Kevin Ross Holme

Karen J Watson-Straughan

Douglas L Hitchin

Kevin C Dines

Timothy C Gahman

Methods for treating erectile dysfunction using tetrahydroisoquinoline aromatic amines that function as melanocortin receptor ligands.

Treatment of erectile dysfunction using isoquinoline compound melanocortin receptor ligands

Methods for treating sexual dysfunction, such as erectile dysfunction or sexual arousal disorder, with a compound having the generic formula X &mdash;X -(D)Phe-Arg-(D)Trp-X . A particularly useful compound is HP-228, which has the formula Ac-Nle-Gln-His-(D)Phe-Arg-(D)Trp-Gly-NH . The invention also provides methods for selecting melanocortin receptor-3 ligands by determining whether a compound modulates the activity of MC-3 as an agonist or antagonist. These methods can be used to screen compound libraries for ligands to treat MC-3-associated conditions. Such conditions include sexual dysfunction, including erectile dysfunction and sexual arousal disorder.

Melanocortin receptor-3 ligands to treat sexual dysfunction

The invention relates to melanocortin receptor ligands and methods of using the ligands to alter or regulate the activity of a melanocortin receptor. The invention further relates to tetrahydroisoquinoline aromatic amines that function as melanocortin receptor ligands and as agents for controlling cytokine-regulated physiologic processes and pathologies, and combinatorial libraries thereof.

Isoquinoline compound melanocortin receptor ligands and methods of using

The present invention relates to an improved three-dimensional cell culture system in which cells are grown on a three-dimensional matrix while cycling the cultures between metabolically favorable and metabolically unfavorable (but noncytotoxic) conditions. The invention is based, at least in part, on the discovery that cycling the cultures in this manner optimizes the formation of extracellular matrix and produces an overall structure that more closely resembles naturally occurring tissue.

Three-dimensional stromal cell and tissue culture system

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San Diego, CA, United States of America

Sandra R Slivka