Other

21st Century Medicine Inc.

Critical Care Research, Inc.

Sandra R Russell

Michael G Federowicz

Brian G Wowk

Michael Federowicz

A novel technique for ventilation and heat exchange is disclosed called Mixed-mode Liquid Ventilation (MMLV). This technique uses an endotracheal catheter to add and remove liquid from the lungs continuously and/or cyclically, and deliver gas at a rate independent of the delivery of liquid. This technique produces small-scale mixing of gas and liquid in the airways, allowing for efficient gas and heat exchange. Medical uses for the technique are disclosed. These uses include induction and reversal of hyperthermia, and hypothermia.

Mixed-mode liquid ventilation gas and heat exchange

A method of cooling and rewarming large organs and tissues at sub-zero temperatures is provided. The method includes perfusion of tissue with inert fluids that remain liquid at very low temperatures. The inert fluids can include fluorocarbons, silicones, or fluorosilicones. Glycol ethers are used as a novel class of cryoprotective agents for organ and tissue preservation. The glycol ethers have improved viscosity, penetration, and glass forming properties.

Method for rapid cooling and warming of biological materials

A method of cryopreserving biological material by administering a cryoprotective agent mixture is provided. The mixture must be produced in a concentration sufficient to permit vitrification. The cryoprotective agent is an alkoxylated organic compound. The method includes administering the cryoprotective agent mixture and cooling the biological material until it is vitrified. Preferred cryoprotective mixtures contain 3 methoxy-1,2 propanediol and 2-methoxy ethanol.

Growing community of inventors

Solana Beach, CA, United States of America

Sandra R Russell