Sofar S.p.a.

Lga Biotecnologie Srl

Sandra Parenti

Alexis Grande

Fabrizio Ferrarini

In the present invention, a new combination is disclosed comprising (i) 5-aminosalicylic acid (5-ASA) or a derivative thereof, or a pharmacologically acceptable salt thereof, and (ii) a group D vitamin, a derivative thereof, a metabolite or analogue, for use in the prevention and/or treatment of colorectal cancer (CRC). A further aspect of the invention is directed to pharmaceutical compositions comprising said combination together with at least one physiologically acceptable excipient and the use thereof in the prevention and/or in the treatment of the colorectal cancer.

Chemoprevention of colorectal cancer

A method is disclosed for the determination of 5-ASA efficacy in preventing and/or treating CRC in a mammalian, which comprises the analysis of the inhibition of the &#x3b2;-catenin pathway in presence of 5-ASA. More in details, the method comprises measuring the expression of at least one gene involved in the regulation of the &#x3b2;-catenin signalling pathway, such as &#x3bc;-protocadherin, E-cadherin, &#x3b2;-catenin, Axin1, ICAT, p21and the expression of onco-suppressor genes, such as KLF4 and CEBP&#x3b1;. Gene expression can be measured in accordance to the methods commonly available in the art such as QRT-PCR and immunohistochemistry.

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Modena, Italy

Sandra Parenti