Illinois State University

University of Antioquia

Universidad De Caldas

Sandra Milena Duque

Ivan Dario Velez Bernal

David Leonardo Cedeño Medina

Rogelio Ocampo Cardona

Luz Amalia Rios Vasquez

Sara Maria Robledo Restrepo

Marjorie Ann Jones

The use of quaternary halogenated ammonium salts for treating leishmaniasis infections and other parasitic diseases is described. Although there have been previous reports in which quaternary ammonium salts are used as antimalarial, antifungal, and antileishmanial compounds, the use of such salts containing a halogenated N-methyl substituent as a therapeutic agent against leishmaniasis had not been reported. The compounds described here, in specific those with a terminal arylalkenyl or diarylalkenyl moiety, are shown to inhibit the growth ofparasites, a known causative agent of leishmaniasis disease. In addition, the series of compounds are also extensive against malaria, Chagas disease, toxoplasmosis, and other parasitic diseases.

Quaternary N-(halomethyl) ammonium salts as therapeutic agents

Growing community of inventors

Manizales, Colombia

Sandra Milena Duque