Koninklijke Philips Corporation N.v.

Tagworks Pharmaceuticals B.v.

Sandra Martina Van Den Bosch

Marc Stefan Robillard

Raffaella Rossin

Bernardus Hendrikus Wilhelmus Hendriks

Gerhardus Wilhelmus Lucassen

Johan Lub

Wolter Ten Hoeve

Torre Michelle Bydlon

Ronny Mathieu Versteegen

Vishnu Vardhan Pully

Vanda Lucia De Carvalho Vittorino De Almeida

Charles Frederik Sio

Matthias Irmscher

Harma Martine Feitsma

Tilman Laeppchen

Christianne Rossette Maria De Witz

The present invention relates to a method for determining a state of tissue sealing during a tissue sealing process. According to the disclosed method, an optical probe beam is used to irradiate a tissue region. A signal indicative of optical scattering in the tissue region is generated from a portion of the optical probe beam that has passed through or been returned by the tissue region. The onset of tissue sealing is indicated by the successive occurrence in time of a turning point and a point of inflection in the optical scattering signal. An energy-based tissue sealing or tissue-cutting device for use in accordance with the method is also disclosed.

Tissue sealing device with optical feedback

Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an E-cyclooctene which has one or more axial substituents.

Pretargeting kit, method and agents used therein

Described is a method, and a combination of agents for used therein, by which an agent administered to a subject can be rapidly cleared from circulation. This is achieved by providing an Administration Agent (e.g. a probe for pretargeting) with a reactive group and providing a Clearing Agent with another reactive group, said reactive groups forming a bio-orthogonally reactive pair. Preferably, the reactive pair comprises a cyclooctene or cyclooctyn as one reactant, and a diene as the other reactant. The method and combination can be used for the removal of any bindable molecule from circulation, such as an excess of a pre-targeting probe in the course of a pre-targeting method, a targeting or imaging agent delivered, or the removal of any biomolecule already present in circulation.

Agents for clearing biomolecules from circulation

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Weert, Netherlands

Sandra Martina Van Den Bosch