Queen's University at Kingston

Sandra Marone

Donald F Weaver

Richard J Riopelle

Gregory M Ross

Igor L Shamovsky

The present invention relates to compositions which inhibit the binding of nerve growth factor to the p75common neurotrophin receptor and methods of use thereof. In one embodiment, the compound which inhibits binding of nerve growth factor to p75comprises, particularly when bound to nerve growth factor, at least two of the following: (1) a first electronegative atom or functional group positioned to interact with Lysof nerve growth factor; (2) a second electronegative atom or functional group positioned to interact with Lysof nerve growth factor; (3) a third electronegative atom or functional group positioned to interact with Lysof nerve growth factor; (4) a fourth electronegative atom or functional group positioned to interact with Lysof nerve growth factor; and (5) a hydrophobic moiety which interacts with the hydrophobic region formed by Ile, Pheand Pheof nerve growth factor.

Method of inhibiting neurotrophin-receptor binding

The present invention relates to compositions which inhibit the binding of nerve growth factor to the p75 common neurotrophin receptor and methods of use thereof. In one embodiment, the compound which inhibits binding of nerve growth factor to p75 comprises, particularly when bound to nerve growth factor, at least two of the following: (1) a first electronegative atom or functional group positioned to interact with Lys of nerve growth factor; (2) a second electronegative atom or functional group positioned to interact with Lys of nerve growth factor; (3) a third electronegative atom or functional group positioned to interact with Lys of nerve growth factor; (4) a fourth electronegative atom or functional group positioned to interact with Lys of nerve growth factor; and (5) a hydrophobic moiety which interacts with the hydrophobic region formed by Ile , Phe and Phe of nerve growth factor.

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Kingston, Canada

Sandra Marone