Pharmacia Corporation

Pharmacia & Upjohn Company

Sandra M Sims

Satish Kumar Singh

Paramita Bandyopadhyay

Shri Valvani

Phil Bryan Bowman

Leslie C Hawley

Daniel C Wade

Lisa A Adams

Syed Hasan

There is provided a pharmaceutical composition for therapeutic or prophylactic administration to a subject having an infective disease or condition or at risk thereof. The composition comprises an aqueous carrier having in solution therein (a) an oxazolidinone antimicrobial drug, for example linezolid, in a therapeutically or prophylactically effective drug concentration that is above the practical limit of solubility of the drug in a substantially isotonic aqueous solution at a physiologically compatible pH, and (b) a pharmaceutically acceptable cyclodextrin compound in a concentration sufficient to maintain the drug in solution at such a drug concentration. The composition is particularly useful for intravenous delivery of the drug.

Solution composition of an oxazolidinone antibiotic drug having enhanced drug loading

Container for linezolid intravenous solution

There is provided a pharmaceutical preservative free composition suitable for topical administration to an eye, the composition comprising (a) an oxazolidinone antimicrobial drug, for example linezolid, in a therapeutically or prophylactically effective drug concentration that is above the practical limit of solubility of the drug in a substantially isotonic aqueous solution at a physiologically compatible pH, and (b) a pharmaceutically acceptable cyclodextrin compound in a concentration sufficient to maintain the drug in solution at such a drug concentration. The composition is particularly useful for the treatment and/or prevention of eye infections due to gram positive bacteria.

Preservative free ophthalmic oxazolidinone antibiotic drug delivery systems

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Portage, MI, United States of America

Sandra M Sims