Bristol-myers Squibb Compnay

Sandra L Quinlan

Bang-Chi Chen

Stephen R Baker

Richard H Spector

Derron Ray Stark

An economical process, amenable to large-scale production, is disclosed for the preparation of 2',3'-didehydro-3'-deoxythymidine (d4T) from 5-methyluridine. The process employs a novel, 5'-,acyl-2'.alpha.-halo-3'.alpha.-alkanesulfonylthymidine intermediate as well as a highly efficient and practical deprotection, isolation and purification procedure for the d4T product.

Preparation of 2',3'-didehydro-3'-deoxythymidine from 5-methyluridine

The present invention concerns an improved process of making d4T from 5-MU. Another aspect of the invention relates to useful intermediates produced during the process.

Preparation of d4T from 5-methyluridine

A process for preparing AZT and comprising the steps of:

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Manlius, NY, United States of America

Sandra L Quinlan