Bristol-myers Squibb Compnay

Bristol-myers Company

Sandra J Hofstead

Kin S Lam

David Willner

Pamela A Trail

Gary R Braslawsky

Robert S Greenfield

H Dalton King

Koji Tomita

James A Matson

James A Bush

Daniel R Schroeder

Brian A Dougherty

Wenying Li

Jacqueline M Mattei

Grace A Hesler

Salvatore Forenza

Zizhuo Xing

Yijun Chen

Thomas T Dabrah

Christopher L Steele

Isolated nucleic acid and amino acid sequences for phenylalanine aminomutase enzyme and methods for purifying this enzyme are provided. Methods for altering biosynthesis of compounds in plant cell cultures are also provided. In particular, methods for altering production of taxanes and taxane-related compounds are provided.

Compositions and methods for altering biosynthesis of taxanes and taxane-related compounds

Provided are drug/ligand compounds of Formula (I): ##STR1## (I) in which

Thioether conjugates

Provided are drug/ligand compounds of Formula (I): ##STR1## in which D is a drug moiety;

An antitumor antibiotic designated BMY-42428 is produced by fermentation of Actinomadura madurae ATCC-53806. The BMY-42428 antibiotic exhibits both antimicrobial and antitumor activities.

Antitumor antibiotic BMY-42428

Kedarcidin is a protein antitumor antibiotic produced by Streptoalloteichus sp. nov. strain L585-6, ATCC 53650. The antibiotic comprises a non-protein chromophore and a single chain polypeptide having 114 amino acid residues.

Antitumor antibiotic kedarcidin

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Middletown, CT, United States of America

Sandra J Hofstead