Imperial Cancer Research Technology, Ltd.

Sandra Gendler

Joyce Taylor-Papadimitriou

Joy Burchell

Antigens are derived from the tandem repeat sequence of the core protein of a human polymorphic epithelial mucin. These antigens include a core protein epitope which is recognized by certain antibodies which also bind certain carcinoma antigens, but not fully processed HPEM glycoprotein as produced by the normal lactating human mammary gland.

Antigens derived from the core protein of the human mammary epithelial mucin

Nucleic acid fragments are described which can be used as probes for detecting one of the strands of the DNA tandem repeat sequence in the gene encoding the core protein of human polymorphic epithelial mucin, or incorporated into an expression vector to encode a portion of the mucin core protein to be used for immunization purposes.

Nucleic acid fragments encoding portions of the core protein of the

Antibodies which bind to the core protein of the human polymorphic epithelial mucin glycoprotein are useful in the diagnosis of cancer.

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London, United Kingdom

Sandra Gendler