The State University of New York

Syracuse University

Sandra Fernandes Denney

William Garrow Kerr

John D Chisholm

Frank A Middleton

The present invention relates to methods and kits for detecting a fusion mRNA transcript or polypeptide encoded by the fusion mRNA transcript. The method includes obtaining a biological sample from a subject and providing one or more reagents capable of binding a fusion mRNA transcript or polypeptide encoded by the fusion mRNA transcript, wherein the fusion mRNA transcript or polypeptide encoded by the fusion mRNA transcript comprises the 3' end of ex on 25 of INPP5D fused to the 5&#x2032; end of ex on 2 of ATG16L1 or the polypeptide encoded by the 3&#x2032; end of ex on 25 of INPP5D fused to the 5&#x2032; end of ex on 2 of ATG16L1, respectively.

Methods and kits for detecting a fusion messenger RNA transcript or a polypeptide encoded by the fusion messenger RNA transcript

The present disclosure provides compositions that inhibit the SH2-containing inositol 5'-phosphatase (SHIP), as well as methods using such compositions for use in treating or ameliorating the effects of a medical condition in a subject.

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Constantia, NY, United States of America

Sandra Fernandes Denney