Migenix, Inc.

Mitokor, Inc.

Sandra Eileen Wiley

Robert E Davis

William Christensen Clevenger

Christen M Anderson

Soumitra S Ghosh

Walter H Moos

Yazhong Pei

Tomas R Szabo

Scott W Miller

Anne N Murphy

Alexander Y Andreyev

Luciano G Frigeri

Gonul Velicelebi

Gonul Velecelebi

Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor

Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor.

Compositions and methods are provided for identifying agents that alter mitochondrial membrane permeability transition. The screening methods generally detect agents that alter the interaction between the mitochondrial adenine nucleotide translocator and cyclophilin D. Such agents may be used, for example, in the treatment of a variety of conditions associated with altered mitochondrial function.

Compositions and methods for determining interactions of mitochondrial components, and for identifying agents that alter such interactions

Compositions and mehtods for determining interactions of mitochondrial components, and for identifying agents that alter such interactions

Growing community of inventors

San Diego, CA, United States of America

Sandra Eileen Wiley