Omeros Corporation

Targetex Kft.

Pharmahungary 2000 Kft.

Sándor Cseh

Jennifer Lynn Gage

Neil S Cutshall

László Ürögdi

Hongkui Zeng

John E Bergmann

Rene Onrust

Derek Johnston

Ákos Papp

Péter Ferdinandy

Gábor Medgyes

György Dormán

Anikó Görbe

Dénes Kónya

István Hajdú

Zsolt Lörincz

Ferenc Tamás Takács

Attila Kis-Tamás

László Kovács

Krisztina Kedvesné Kupai

Csaba Csonka

Tamás Bálint Csont

Ferenc Tamás TAKÁCS

Lazlo Urogdi

Zeng Hongkui

Compounds of general formula (I), salts or solvates thereof and pharmaceutical compositions containing same: 

Inhibitors of matrix metalloproteinases

Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, Bell's palsy, cerebral palsy, sleep disorders, pain, Tourette syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. The compounds have the general structure: wherein m, n, p, x, R, R, R, R, R, R, A and B, are defined herein, including pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting PDE10 in a warm-blooded animal in need of the same.

PDE10 inhibitors and related compositions and methods

Growing community of inventors

Dunakeszi, Hungary

Sándor Cseh