Sandoz Gmbh

Sandoz Pharm. Corp.

Sandor Barcza

James B Hendrickson

Faizulla G Kathawala

This invention relates to chiral compositions.

Chiral stationary phases and columns for chromatographic resolution

This disclosure relates to the aspermatogenesis activity of compounds of the following formula: ##STR1## where R.sub.1 and R.sub.2 each independently represent hydrogen, halo having an atomic weight of about 19 to 36, lower alkyl having 1 to 4 carbon atoms, lower alkoxy having 1 to 4 carbon atoms, trifluoromethyl, or

Disilacyclohexane derivatives in anti-fertility agents

Sulfur and silicon-containing amides, e.g. N-5-sila-3-thia-5,5-dimethyl-pentadecanoyl-1-phenyl-2-(4-methylphenyl)-eth ylamine, are useful as anti-atherosclerotic agents. The amides are obtainable by acylation of a primary amine (the substituents on the amine being of the aralkyl phenyl, tryptophanyl, benzocycloalkyl-type) with a corresponding sulfur and silicon-containing carboxylic acid (or active form thereof).

Sulfur and silicon-containing fatty acid amides

Compounds of the formula ##STR1## in which R.sup.1 is a mono-silicon-containing hydrocarbyl radical having up to 35 carbon atoms;

Para-amino benzoic and phenylacetic acid derivatives

Silicon-containing amides, e.g., N-[1'-phenyl-2'-(4'-methylphenyl)ethyl]-2,2,6,6-tetramethyl-1-oxa-2,6-disi lacyclohexane-4-carboxamide, are useful as anti-atherosclerotic agents. The amides are obtainable by acylation of a primary amine (the substituents on the amine being of the aralkyl phenyl, tryptophanyl, benzocycloalkyl-type) with a corresponding silicon-containing carboxylic acid (or active form thereof).

1-Oxa-2,6-disilacyclohexane-4-carboxamides

This disclosure describes compounds of the formula ##STR1## wherein n is 3, 5 or 7, and

4,4'-(Alkanediyl)-bis(2,2,6,6-tetraalkyl

The final products are compounds of the formula ##STR1## wherein (a) each of R.sup.1, R.sup.2 and R.sup.3 alkyl having from 1 to 22 carbon atoms; or

Silicon-bearing carboxylic acids and amides

This disclosure describes compounds of the formula ##STR1## wherein R.sub.1 represents ##STR2## and R.sub.2, R.sub.3, R.sub.4 and R.sub.5 each independently represent lower alkyl having 1 to 2 carbon atoms, and

Substituted 1-oxa-4-aza-2,6-disilacyclohexanes and use thereof

This disclosure describes novel compounds of the formula: ##STR1## where R.sub.1 and R.sub.2 each independently represent hydrogen, halo having an atomic weight of about 19 to 36, lower alkyl, lower alkoxy,

Substituted 1-oxa-4-aza-2,6-disilacyclohexanes

Compounds of the following structure ##STR1## where R.sub.1 represents H or alkyl having 1-5 carbon atoms,

Substituted 3,1-benzazasilines

Benzazasilin-4-ones of the formula ##STR1## where R.sub.1 represents H or alkyl of 1-5 carbon atoms,

Substituted 3,1-benzazasilin-4-ones

2,4-Disubstituted-4b,5,6,7,8,8a,9,10-octahydro-9-oxo-phenanthrenes e.g., 2,4-dimethoxy-4b,5,6,7,8,8a,9,10-octahydro-9-oxo-phenanthrene are useful as hypolipidemic agents.

2,4-Disubstituted-4b,5,6,7,8,8a,9,10-octahydro-9-oxo-phenanthrenes

1-succinoyl-2,4-disubstituted-4b,5,6,7,8,8a,9,10-octahydro-9-oxo-phenanthre nes, e.g., 1-succinoyl-2,4-dimethoxy-4b,5,6,7,8,8a,9,10-octahydro-9-oxo-phenanthrene are prepared by treating a corresponding 2,4-dimethoxy-4b,5,6,7,8,8a,9,10-octahydro-9-oxo-phenanthrene with a Friedel Crafts catalyst in the presence of an organic solvent, and are useful as hypolipidemic agents.

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West Orange, NJ, United States of America

Sandor Barcza