Arizona State University

University of Houston System

Sandipan Roy Chowdhury

Sidney M Hecht

Omar Khdour

Rakesh Paul

Larisa (Liza) Dedkova

Rumit Maini

Indrajit Bandyopadhyay

Nishant P Visavadiya

Poulami Talukder

Sidney Hecht

Indrajit Bandyopadhay

Alexander Statsyuk

Modified ribosomes that were selected using a dipeptidyl-puromycin aminonucleoside are used to mediate site-specific incorporation of one or more peptides and peptidomimetics into protein in a cell free translation system. In addition, new fluorescent dipeptidomimetics have been synthesized and incorporated into proteins, as well as modified proteins containing one or more non-naturally occurring dipeptides.

Ribosome-mediated incorporation of peptides and peptidomimetics

The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R, R, R, R, subscript m and n, have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

Therapeutic compounds

The invention provides compounds formula (I) and salts thereof:  wherein R, R, R, Rand Y have any of the values defined in the specification. The compounds are useful for treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.

Substituted phenothiazines as mitochondrial agents

The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables R, R, R, R, subscipt m and n, have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

The present disclosure provides phenothiazine derivative compounds and salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.

The present disclosure provides methods for identifying therapeutic agents that are multifunctional radical quenchers. It also provides compounds of formula: and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.

Multifunctional radical quenchers for the treatment of mitochondrial dysfunction

The present disclosure provides compounds of formula (I): compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.

The present disclosure provides methods for identifying therapeutic agents that are multifunctional radical quenchers. It also provides compounds of formula (I), (II), or (II-A): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.

Growing community of inventors

Tempe, AZ, United States of America

Sandipan Roy Chowdhury