Sun Pharma Advanced Research Company Limited

Sandeep Pankajkumar Pathak

Trinadha Rao Chitturi

Bhavesh Mohanbhai Panchal

Jayraj Dilipbhai Aradhye

Biswajit Samanta

Rajan Kumar Pal

Kaushik Dhanjibhai Prajapati

A selective estrogen receptor degrader (SERD), a compound 3-(3,5-difluorophenyl)-2-[4-[(E)-3-[3-(fluoromethyl)azetidin-1-yl]prop-1-enyl]phenyl]-4-methyl-2H-chromen-7-ol, and its S enantiomer, (2S)-3-(3,5-difluorophenyl)-2-[4-[(E)-3-[3-(fluoromethyl)azetidin-1-yl]prop-1-enyl]phenyl]-4-methyl-2H-chromen-7-ol, or pharmaceutically acceptable salts thereof. Also provided are processes for their preparation. Also provided for is the use of these compounds for the treatment of diseases which are related to modulation of estrogen receptors, such as ER-positive breast cancer.

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Vadodara, India

Sandeep Pankajkumar Pathak