Osiris Therapeutics, Inc.

University of California

Sandeep Dhall

Alla Danilkovitch

Jin-Qiang Kuang

Steven Michael Sinclair

Anne Allgood Lerch

Matthew Robert Moorman

Anthony John Melchiorri

Malathi Sathyamoorthy

Yishan Liu

Mena Schiano Lo Moriello

Manuela Martins-Green

Danh Do

Neal Schiller

Disclosed are compositions comprising a non-homogenized chorionic matrix, a homogenized amniotic matrix and a homogenized UC (UC) matrix, wherein the non-homogenized chorionic matrix comprises viable cells. Disclosed are methods of making the compositions disclosed herein comprising preparing a non-homogenized chorionic matrix, preparing a homogenized amniotic matrix, preparing a homogenized UC matrix, and combining the non-homogenized chorionic matrix, the non-homogenized chorionic matrix, and the homogenized UC matrix. Disclosed are methods of treating a tissue injury or chronic pain comprising administering any of the disclosed compositions to an area of a subject comprising a tissue injury.

Human tissue derived compositions and uses thereof

A method of treating a chronic wound in a subject in need of such treatment is provided. The method includes administering to the subject at least one antioxidant agent in an amount effective to treat the wound. In some versions, the antioxidant agent is &#x3b1;-tocopherol or N-acetyl cysteine, or a combination of these compounds. In other versions, a method of preparing a chronic wound animal model is provided.

Wound healing

Growing community of inventors

Elkridge, MD, United States of America

Sandeep Dhall