Licentia Oy

Labmaster Oy

Samuli Franssila

Risto Kostiainen

Tapio Kotiaho

Antti Niskanen

Sakari Kulmala

Lauri Sainiemi

Raimo Ketola

Tiina Ylinen-Hinkka

Seppo Marttila

Teemu Nissila

The invention relates to integrated electronic chip (IEChip) cartridge devices which are used in hot electron-induced electrochemiluminescence methods and to instrumentation based on the electrical excitation of label molecules with subsequent measurement of luminescence in order to quantitate analyte concentrations especially in bioaffinity assays, especially outside of central laboratories.

Accurate integrated low-cost electrode chips for point-of-need analysis and a method of utilization in hot electron-induced electrochemiluminescent systems

The invention relates to an electrospray ionization (ESI) device for forming a stream of ionized sample molecules. The device comprises a sample introduction zone for receiving a liquid-form sample, a tip for spraying the sample into aerosol or gaseous form, and a flow channel connecting the sample introduction zone and the tip. According to the invention, the flow channel comprises an array of transversely oriented microstructures adapted to passively transport the liquid-form sample introduced to the sample introduction zone to the tip by means of capillary forces. The invention concerns also a manufacturing method and applications of the ESI device, in particular mass spectrometry. The device can be used without external pumping of sample liquid.

Micropillar array electrospray chip

A method and an apparatus for examining a sample by means of mass spectrometry. According to the method, the solution comprising the sample to be examined is vaporized in a vaporizer, the vaporized sample solution is sprayed, using a gas flow, into a corona discharge zone, where the examined sample is ionised according to the APCI method, using a corona discharge, to generate gas phase ions, and the ions are separated and directed to a detector. According to the present invention, a vaporizer is used, which is fabricated as a micromechanical structure which comprises the flow channels for the solution and for the carrier gas possibly used for feeding the solution, as well as the heater of the vaporizer, and which are all included in a monolithic structure. The solution is especially suitable for cases in which a very sensitive analysing technique is needed, or in which the available sample quantity is very small (less than 1 &#x3bc;L).

Method and apparatus for mass spectrometric analysis

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Helsinki, Finland

Samuli Franssila