Olon S.p.a.

Solmag S.p.a.

Samuele Frigoli

Claudio Fuganti

Marco Alpegiani

Davide Longoni

Stefano Serra

Tamara Danelli

Roberta Pizzocaro

Francesco Pizzocaro

Angelo Bedeschi

Paolo Tubertini

Disclosed is a process for the preparation of Enzalutamide comprising the reaction (Scheme 2), wherein R can be alkyl, aryl, aryl-alkyl or heterocyclyl. 

Process for the preparation of enzalutamide

Disclosed is asenapine phosphate of formula (I) and its enantiomer (I) which can be used to prepare asenapine maleate. Further disclosed is a monoclinic crystalline form of asenapine maleate. 

Crystalline salts of asenapine

The invention relates to a process for the preparation of duloxetine (1a), comprising the reaction between 1-fluoronaphthalene and 3-N,N-dimethylamino-1-(2-thienyl)-propan-1-ol in the presence of 1,3-dimethyl-2-oxo-hexahydropyrimidine (DMPU) as the solvent; a method for the identification of duloxetine enantiomers and for the determination of its optical purity is also disclosed. 

Process for the preparation of 1-naphthol mixed ethers and intermediates of crystalline forms of (+) and (&#x2212;)-duloxetine

Tazarotene is prepared by deoxygenation of the corresponding S-oxide, in turn obtained according to two alternative synthetic pathways.

Process for the preparation of Tazarotene

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Garbagnate Milanese, Italy

Samuele Frigoli