Csl Limited

Merck + Co., Inc.

Samuel Wright

Reinhard Franz Bolli

Martin A Imboden

Marcel Waelchli

Kang Cheng

Tsuei-Ju Wu

A reconstituted high density lipoprotein formulation having relatively low toxicity comprises an apolipoprotein such as ApoAI or fragment thereof, a lipid and a detergent at a level which is about 5-50% of that which would normally cause liver toxicity upon administration to a human. The lipid is optimally phosphatidylcholine at about 30-50 g/L and the molar ratio of apolipoprotein:lipid is optimally in the range 1:40 to 1:75. The formulation is useful for treating diseases or conditions such as cardiovascular disease, hypercholesterolaemia and hypocholesterolaemia inclusive of acute coronary syndrome (ACS), atherosclerosis and myocardial infarction.

Reconstituted high density lipoprotein formulation and production method thereof

This invention provides a drug combination comprised of a thyroid hormone receptor beta agonist with a fibrate in therapeutically effective amounts, which is useful for reducing cholesterol synthesis, lowering plasma cholesterol levels and lowering plasma triglyceride levels.

Anti-hypercholesterolemic drug combination

Growing community of inventors

Westfield, NJ, United States of America

Samuel Wright