Ortho Pharmaceutical Corporation

Monsanto Company

Samuel S Asculai

Alfred B Kupferberg, Deceased

By Meyer Halpern, Coexecutor

John H Johnson

Joseph E Fields

By Beatrice Kupferberg, Coexecutrix

Eva J Brandt

The disclosure relates to a method of producing an immune response in a warm-blooded animal comprising administering to said animal from about 0.1 to about 100 mg/Kg of body weight of a composition selected from the group consisting of a copolymer of olefin monomer and polycarboxylic anhydride having an average molecular weight of from about 300 to about 1500 in which said copolymer is derivatized to contain (a) half-amide, half-carboxyl acid groups and (b) imide groups in which said imide groups comprise from about 5% to about 40% by weight of said derivatized groups, and the pharmaceutically acceptable cationic salt derivatives of said derivatized copolymers.

Method of producing immune response by administering polymeric

A method is disclosed for detecting the presence of migration inhibitory factor (MIF) which comprises reacting a test solution containing an unknown amount of MIF antigen, a known amount of MIF antigen which has been radiolabeled, a known amount of antibodies to MIF, and thereafter precipitating and removing the resulting immune complex and measuring the radioactive content thereof, said antibodies to MIF being produced by immunization of animals with MIF antigen obtained from the growth of human lymphocytes under tissue culture conditions.

Radioimmunoassay of MIF

The disclosure relates to copolymers of olefin monomers having from 2 to about 4 carbon atoms and .alpha.,.beta.-unsaturated polycarboxylic anhydrides having from 4 to about 6 carbon atoms, having an average molecular weight of from about 300 to about 1500, and derivatized to contain both a half-amide, half-carboxylate salt function and an imide function in which said imide function comprises from about 5% to about 40% of said derivatized function. The utility of these copolymers in the management of tumor therapy to prevent tumor recurrence or development of metastases by an immunoregulatory mechanism has been demonstrated in rats and mice.

Polymeric immunoregulatory agents containing half-amide/half

Nonionic surface active anti-viral agents are described. The anti-viral agents are nonionic surfactants and are useful as inactivating agents for herpes simplex.

Nonionic surface active anti-viral agents

Nonionic surface active anti-herpes simplex viral agents

A method for detecting the end point in immunochemical and serodiagnostic tests involving agglutination is described wherein the test is carried out on a curved slide having a curvature sufficient to produce a discernible pattern at the end point.

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St. Louis, MO, United States of America

Samuel S Asculai